Erwinia asparaginase achieves therapeutic activity after pegaspargase allergy: A report from the Children's Oncology Group

Wanda L. Salzer, Barbara Asselin, Jeffrey G. Supko, Meenakshi Devidas, Nicole A. Kaiser, Paul Plourde, Naomi J. Winick, Gregory H. Reaman, Elizabeth Raetz, William L. Carroll, Stephen P. Hunger

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

AALL07P2 evaluated whether substitution of Erwinia asparaginase 25 000 IU/m2 for 6 doses given intramuscularly Monday/Wednesday/Friday (M/W/F) to children and young adults with acute lymphoblastic leukemia and clinical allergy to pegaspargase would provide a 48-hour nadir serum asparaginase activity (NSAA) ≥0.10 IU/mL. AALL07P2 enrolled 55 eligible/evaluable patients. NSAA ≥0.1 IU/mL was achieved in 38 of 41 patients (92.7%) with acceptable samples 48 hours and in 38 of 43 patients (88.4%) 72 hours after dosing during course 1. Among samples obtained during all courses, 95.8% (252 of 263) of 48-hour samples and 84.5% (125 of 148) of 72-hour samples had NSAA ≥0.10-IU/mL. Pharmacokinetic parameters were estimated by fitting the serum asparaginase activity-time course for all 6 doses given during course 1 to a 1-compartment open model with first order absorption. Erwinia asparaginase administered with this schedule achieved therapeutic NSAA at both 48 and 72 hours and was well tolerated with no reports of hemorrhage, thrombosis, or death, and few cases of grade 2 to 3 allergic reaction (n 5 6), grade 1 to 3 hyperglycemia (n5 6), or grade 1 pancreatitis(n51). Following allergy to pegaspargase, Erwinia asparaginase 25 000 IU/m2 × 6 intramuscularly M/W/F can be substituted for a single dose of pegaspargase.

Original languageEnglish (US)
Pages (from-to)507-514
Number of pages8
JournalBlood
Volume122
Issue number4
DOIs
StatePublished - Jul 25 2013

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Fingerprint Dive into the research topics of 'Erwinia asparaginase achieves therapeutic activity after pegaspargase allergy: A report from the Children's Oncology Group'. Together they form a unique fingerprint.

  • Cite this

    Salzer, W. L., Asselin, B., Supko, J. G., Devidas, M., Kaiser, N. A., Plourde, P., Winick, N. J., Reaman, G. H., Raetz, E., Carroll, W. L., & Hunger, S. P. (2013). Erwinia asparaginase achieves therapeutic activity after pegaspargase allergy: A report from the Children's Oncology Group. Blood, 122(4), 507-514. https://doi.org/10.1182/blood-2013-01-480822