Abstract
Chemical examination of an extract from an Erythrobacter sp. isolated from mangrove sediments yielded erythrazoles A (1) and B (2). The erythrazoles are of mixed biosynthetic origin containing a tetrasubstituted benzothiazole, an appended diterpene side chain, and a glycine unit. Erythrazole B is cytotoxic to a panel of non-small cell lung cancer (NSCLC) cell lines, with IC 50 values of 1.5, 2.5, and 6.8 μM against H1325, H2122, and HCC366, respectively.
Original language | English (US) |
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Pages (from-to) | 6580-6583 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 13 |
Issue number | 24 |
DOIs | |
State | Published - Dec 16 2011 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry