Erythrazoles A-B, cytotoxic benzothiazoles from a marine-derived erythrobacter sp.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Chemical examination of an extract from an Erythrobacter sp. isolated from mangrove sediments yielded erythrazoles A (1) and B (2). The erythrazoles are of mixed biosynthetic origin containing a tetrasubstituted benzothiazole, an appended diterpene side chain, and a glycine unit. Erythrazole B is cytotoxic to a panel of non-small cell lung cancer (NSCLC) cell lines, with IC 50 values of 1.5, 2.5, and 6.8 μM against H1325, H2122, and HCC366, respectively.

Original languageEnglish (US)
Pages (from-to)6580-6583
Number of pages4
JournalOrganic Letters
Volume13
Issue number24
DOIs
StatePublished - Dec 16 2011

Fingerprint

Sphingomonadaceae
Benzothiazoles
glycine
cultured cells
lungs
sediments
examination
cancer
Cells
Diterpenes
Non-Small Cell Lung Carcinoma
Glycine
Sediments
Cell Line
erythrazole B
erythrazole A

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Erythrazoles A-B, cytotoxic benzothiazoles from a marine-derived erythrobacter sp. / Hu, Youcai; MacMillan, John B.

In: Organic Letters, Vol. 13, No. 24, 16.12.2011, p. 6580-6583.

Research output: Contribution to journalArticle

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