Erythrocyte morphology in women with severe preeclampsia and eclampsia. Preliminary observations with scanning electron microscopy

F. Gary Cunningham, Thomas Lowe, Steve Guss, Ruble Mason

Research output: Contribution to journalArticle

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Abstract

Scanning electron microscopy was used to study the morphologic characteristics of erythrocytes in women with preeclampsia and eclampsia. In nine nulliparous women with eclampsia, the proportion of abnormal red cells (schistocytes, echinocytes, and spherocytes) was significantly greater than in 12 normally pregnant control women (p < 0.001). Likewise, the proportion of these abnormal erythrocyte forms was significantly greater in 12 nulliparous women with preeclampsia than in 25 normally pregnant control women (p = 0.009). Six women with mild pregnancy-induced hypertension without proteinuria were studied before and after magnesium sulfate therapy had been given, and no differences in the proportion of abnormal erythrocyte forms were found. Evidence for microangiopathic hemolysis, manifest by reticulocytosis and thrombocytopenia, was apparent with eclampsia, although only reticulocytosis was identified in women with preeclampsia. There was evidence for hepatic dysfunction in more than half of the women with eclampsia, and in nearly one third of those with preeclampsia. We speculate that compositional changes in the membrane, induced by plasma/erythrocyte lipid interchanges, which are predisposed by normal pregnancy and amplified by severe preeclampsia, especially in the presence of liver dysfunction, may have participated in the genesis of the red cell abnormalities observed. Furthermore, these abnormalities in the cell membrane may increase erythrocyte susceptibility to microangiopathic hemolysis.

Original languageEnglish (US)
Pages (from-to)358-363
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume153
Issue number4
DOIs
StatePublished - Oct 15 1985

Fingerprint

Eclampsia
Pre-Eclampsia
Electron Scanning Microscopy
Erythrocytes
Abnormal Erythrocytes
Reticulocytosis
Hemolysis
Pregnant Women
Spherocytes
Cell Membrane
Magnesium Sulfate
Pregnancy Induced Hypertension
Proteinuria
Thrombocytopenia
Liver Diseases
Lipids
Pregnancy
Liver

Keywords

  • eclampsia
  • Erythrocytes
  • morphologic characteristics
  • preeclampsia
  • scanning electron microscopy

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Erythrocyte morphology in women with severe preeclampsia and eclampsia. Preliminary observations with scanning electron microscopy. / Cunningham, F. Gary; Lowe, Thomas; Guss, Steve; Mason, Ruble.

In: American Journal of Obstetrics and Gynecology, Vol. 153, No. 4, 15.10.1985, p. 358-363.

Research output: Contribution to journalArticle

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