Erythropoietin improves synaptic transmission during and following ischemia in rat hippocampal slice cultures

Astrid Weber, Rolf F. Maier, Ulrike Hoffmann, Martin Grips, Marc Hoppenz, Ayse G. Aktas, Uwe Heinemann, Michael Obladen, Sebastian Schuchmann

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Erythropoietin (EPO) prevents neuronal damage following ischemic, metabolic, and excitotoxic stress. In this study evoked extracellular field potentials (FP) were used to investigate the effect of EPO on synaptic transmission in hippocampal slice cultures. EPO treated cultured slices (40 units/ml for 48 h) showed significantly increased FP during and following oxygen and glucose deprivation compared with untreated control slices. The addition of the Jak2 inhibitor AG490 (50 μM for 48 h) blocked the EPO effect. These data suggest that EPO improves synaptic transmission during and following ischemia in hippocampal slice cultures.

Original languageEnglish (US)
Pages (from-to)305-311
Number of pages7
JournalBrain Research
Volume958
Issue number2
DOIs
StatePublished - Dec 27 2002
Externally publishedYes

Keywords

  • Erythropoietin
  • Hippocampal slice culture
  • Ischemia
  • Neuroprotection
  • Synaptic transmission

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Erythropoietin improves synaptic transmission during and following ischemia in rat hippocampal slice cultures'. Together they form a unique fingerprint.

Cite this