Escitalopram pharmacogenetics: CYP2C19 relationships with dosing and clinical outcomes in autism spectrum disorder

Jeffrey R. Bishop, Fedra Najjar, Leah H. Rubin, Stephen J. Guter, Thomas Owley, Matthew W. Mosconi, Suma Jacob, Edwin H. Cook

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background and aim Selective serotonin reuptake inhibitors such as escitalopram are commonly used to treat patients with autism spectrum disorder (ASD), but there are individual differences in treatment response and tolerability. CYP2C19 encodes the primary enzyme responsible for escitalopram metabolism and we investigated whether polymorphisms in CYP2C19 were related to symptoms and dosing in a pharmacogenetic study of ASD. Participants and methods Participants completed the Aberrant Behavior Checklist - Community Version (ABC-CV) weekly for 6 weeks. Escitalopram was initiated at a dose of 2.5 mg per day, with weekly increases to 20 mg unless intolerable side-effects occurred. Three CYP2C19 metabolizer groups, including ultrarapid, extensive, and reduced metabolizers, were examined in relation to symptom improvement and tolerated dose. Results ABC-CV scores improved over the course of treatment (P

Original languageEnglish (US)
Pages (from-to)548-554
Number of pages7
JournalPharmacogenetics and Genomics
Volume25
Issue number11
DOIs
StatePublished - Nov 11 2015

Keywords

  • Autism spectrum disorder
  • CYP2C19
  • Escitalopram

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Molecular Medicine
  • Genetics(clinical)

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    Bishop, J. R., Najjar, F., Rubin, L. H., Guter, S. J., Owley, T., Mosconi, M. W., Jacob, S., & Cook, E. H. (2015). Escitalopram pharmacogenetics: CYP2C19 relationships with dosing and clinical outcomes in autism spectrum disorder. Pharmacogenetics and Genomics, 25(11), 548-554. https://doi.org/10.1097/FPC.0000000000000173