Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

Olivier Berton; Colleen A. McClung; Ralph J. DiLeone; Vaishnav Krishnan; William Renthal; Scott J. Russo; Danielle Graham; Nadia M. Tsankova; Carlos A. Bolanos; Maribel Rios; Lisa M Monteggia; David W Self; Eric J. Nestler

doi:10.1126/science.1120972

Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

Olivier Berton, Colleen A. McClung, Ralph J. DiLeone, Vaishnav Krishnan, William Renthal, Scott J. Russo, Danielle Graham, Nadia M. Tsankova, Carlos A. Bolanos, Maribel Rios, Lisa M Monteggia, David W Self, Eric J. Nestler

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Abstract

Mice experiencing repeated aggression develop a long-lasting aversion to social contact, which can be normalized by chronic, but not acute, administration of antidepressant. Using viral-mediated, mesolimbic dopamine pathway-specific knockdown of brain-derived neurotrophic factor (BDMF), we showed that BDNF is required for the development of this experience-dependent social aversion. Gene profiling in the nucleus accumbens indicates that local knockdown of BDNF obliterates most of the effects of repeated aggression on gene expression within this circuit, with similar effects being produced by chronic treatment with antidepressant. These results establish an essential role for BDNF in mediating long-term neural and behavioral plasticity in response to aversive social experiences.

Original language	English (US)
Pages (from-to)	864-868
Number of pages	5
Journal	Science
Volume	311
Issue number	5762
DOIs	https://doi.org/10.1126/science.1120972
State	Published - Feb 10 2006

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title = "Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress",

abstract = "Mice experiencing repeated aggression develop a long-lasting aversion to social contact, which can be normalized by chronic, but not acute, administration of antidepressant. Using viral-mediated, mesolimbic dopamine pathway-specific knockdown of brain-derived neurotrophic factor (BDMF), we showed that BDNF is required for the development of this experience-dependent social aversion. Gene profiling in the nucleus accumbens indicates that local knockdown of BDNF obliterates most of the effects of repeated aggression on gene expression within this circuit, with similar effects being produced by chronic treatment with antidepressant. These results establish an essential role for BDNF in mediating long-term neural and behavioral plasticity in response to aversive social experiences.",

author = "Olivier Berton and McClung, {Colleen A.} and DiLeone, {Ralph J.} and Vaishnav Krishnan and William Renthal and Russo, {Scott J.} and Danielle Graham and Tsankova, {Nadia M.} and Bolanos, {Carlos A.} and Maribel Rios and Monteggia, {Lisa M} and Self, {David W} and Nestler, {Eric J.}",

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T1 - Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

AU - Berton, Olivier

AU - McClung, Colleen A.

AU - DiLeone, Ralph J.

AU - Krishnan, Vaishnav

AU - Renthal, William

AU - Russo, Scott J.

AU - Graham, Danielle

AU - Tsankova, Nadia M.

AU - Bolanos, Carlos A.

AU - Rios, Maribel

AU - Monteggia, Lisa M

AU - Self, David W

AU - Nestler, Eric J.

PY - 2006/2/10

Y1 - 2006/2/10

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AB - Mice experiencing repeated aggression develop a long-lasting aversion to social contact, which can be normalized by chronic, but not acute, administration of antidepressant. Using viral-mediated, mesolimbic dopamine pathway-specific knockdown of brain-derived neurotrophic factor (BDMF), we showed that BDNF is required for the development of this experience-dependent social aversion. Gene profiling in the nucleus accumbens indicates that local knockdown of BDNF obliterates most of the effects of repeated aggression on gene expression within this circuit, with similar effects being produced by chronic treatment with antidepressant. These results establish an essential role for BDNF in mediating long-term neural and behavioral plasticity in response to aversive social experiences.

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Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

Abstract

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