TY - JOUR
T1 - Estimating the number of protein folds and families from complete genome data
AU - Wolf, Yuri I.
AU - Grishin, Nick V.
AU - Koonin, Eugene V.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2000/6/16
Y1 - 2000/6/16
N2 - Using the data on proteins encoded in complete genomes, combined with a rigorous theory of the sampling process, we estimate the total number of protein folds and families, as well as the number of folds and families in each genome. The total number of folds in globular, water-soluble proteins is estimated at about 1000, with structural information currently available for about one-third of that number. The sequenced genomes of unicellular organisms encode from approximately 25 %, for the minimal genomes of the Mycoplasmas, to 70-80 % for larger genomes, such as Escherichia coli and yeast, of the total number of folds. The number of protein families with significant sequence conservation was estimated to be between 4000 and 7000, with structures available for about 20 % of these. (C) 2000 Academic Press.
AB - Using the data on proteins encoded in complete genomes, combined with a rigorous theory of the sampling process, we estimate the total number of protein folds and families, as well as the number of folds and families in each genome. The total number of folds in globular, water-soluble proteins is estimated at about 1000, with structural information currently available for about one-third of that number. The sequenced genomes of unicellular organisms encode from approximately 25 %, for the minimal genomes of the Mycoplasmas, to 70-80 % for larger genomes, such as Escherichia coli and yeast, of the total number of folds. The number of protein families with significant sequence conservation was estimated to be between 4000 and 7000, with structures available for about 20 % of these. (C) 2000 Academic Press.
KW - Logarithmic distribution
KW - Protein structure classification
KW - Sampling
KW - Structural genomics
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U2 - 10.1006/jmbi.2000.3786
DO - 10.1006/jmbi.2000.3786
M3 - Article
C2 - 10843846
AN - SCOPUS:0034674175
VL - 299
SP - 897
EP - 905
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
SN - 0022-2836
IS - 4
ER -