Estimation of labeling efficiency in pseudocontinuous arterial spin labeling

Sina Aslan, Feng Xu, Peiying L. Wang, Jinsoo Uh, Uma S. Yezhuvath, Matthias Van Osch, Hanzhang Lu

Research output: Contribution to journalArticle

158 Citations (Scopus)

Abstract

Pseudocontinuous arterial spin labeling MRI is a new arterial spin labeling technique that has the potential of combining advantages of continuous arterial spin labeling and pulsed arterial spin labeling. However, unlike continuous arterial spin labeling, the labeling process of pseudocontinuous arterial spin labeling is not strictly an adiabatic inversion and the efficiency of labeling may be subject specific. Here, three experiments were performed to study the labeling efficiency in pseudocontinuous arterial spin labeling MRI. First, the optimal labeling position was determined empirically to be approximately 84 mm below the anterior commissure-posterior commissure line in order to achieve the highest sensitivity. Second, an experimental method was developed to utilize phase-contrast velocity MRI as a normalization factor and to estimate the labeling efficiency in vivo, which was founded to be 0.86 ± 0.06 (n = 10, mean ± standard deviation). Third, we compared the labeling efficiency of pseudocontinuous arterial spin labeling MRI under normocapnic and hypercapnic (inhalation of 5% CO2) conditions and showed that a higher flow velocity in the feeding arteries resulted in a reduction in the labeling efficiency. In summary, our results suggest that labeling efficiency is a critical parameter in pseudocontinuous arterial spin labeling MRI not only in terms of achieving highest sensitivity but also in quantification of absolute cerebral blood flow in milliliters per minute per 100 g. We propose that the labeling efficiency should be estimated using phase-contrast velocity MRI on a subject-specific basis.

Original languageEnglish (US)
Pages (from-to)765-771
Number of pages7
JournalMagnetic Resonance in Medicine
Volume63
Issue number3
DOIs
StatePublished - Mar 2010

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Cerebrovascular Circulation
Inhalation
Arteries

Keywords

  • ASL MRI
  • Cerebral blood flow
  • Hypercapnia
  • Labeling efficiency
  • pCASL
  • Perfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Aslan, S., Xu, F., Wang, P. L., Uh, J., Yezhuvath, U. S., Van Osch, M., & Lu, H. (2010). Estimation of labeling efficiency in pseudocontinuous arterial spin labeling. Magnetic Resonance in Medicine, 63(3), 765-771. https://doi.org/10.1002/mrm.22245

Estimation of labeling efficiency in pseudocontinuous arterial spin labeling. / Aslan, Sina; Xu, Feng; Wang, Peiying L.; Uh, Jinsoo; Yezhuvath, Uma S.; Van Osch, Matthias; Lu, Hanzhang.

In: Magnetic Resonance in Medicine, Vol. 63, No. 3, 03.2010, p. 765-771.

Research output: Contribution to journalArticle

Aslan, S, Xu, F, Wang, PL, Uh, J, Yezhuvath, US, Van Osch, M & Lu, H 2010, 'Estimation of labeling efficiency in pseudocontinuous arterial spin labeling', Magnetic Resonance in Medicine, vol. 63, no. 3, pp. 765-771. https://doi.org/10.1002/mrm.22245
Aslan, Sina ; Xu, Feng ; Wang, Peiying L. ; Uh, Jinsoo ; Yezhuvath, Uma S. ; Van Osch, Matthias ; Lu, Hanzhang. / Estimation of labeling efficiency in pseudocontinuous arterial spin labeling. In: Magnetic Resonance in Medicine. 2010 ; Vol. 63, No. 3. pp. 765-771.
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