Knowledge of the physical distance separating polymorphic markers which flank a region of interest can be usefully exploited in positional cloning methodology. We present a mathematical model for estimating this distance based on simple conditions generally met in practice. We illustrate estimation and construction of confidence intervals based on the model with data from a recent positional cloning experiment.
|Original language||English (US)|
|Number of pages||7|
|Publication status||Published - 1999|
- Polymorphic markers
- Positional cloning
ASJC Scopus subject areas
- Statistics and Probability