Estimation of physical distance in the genome through probabilistic analysis of marker density and Yeast Artificial Chromosome (YAC) size

James A. Koziol, Bruce Beutler

Research output: Contribution to journalArticle


Knowledge of the physical distance separating polymorphic markers which flank a region of interest can be usefully exploited in positional cloning methodology. We present a mathematical model for estimating this distance based on simple conditions generally met in practice. We illustrate estimation and construction of confidence intervals based on the model with data from a recent positional cloning experiment.

Original languageEnglish (US)
Pages (from-to)251-257
Number of pages7
JournalBiometrical Journal
Issue number2
Publication statusPublished - 1999



  • Polymorphic markers
  • Positional cloning
  • STSs
  • YACs

ASJC Scopus subject areas

  • Statistics and Probability

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