Estrogen and androgen production rates in two brothers with reifenstein syndrome

Alireza Guerami, Jim Griffin III, William J. Kovacs, Placido B. Grino, Paul C. Macdonald, Jean D. Wilson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Defects of the androgen receptor in 46,XY individuals cause aberrant virilization that varies from a female phenotype to men with minor defects. More severely affected individuals also develop gynecomastia associated with enhanced estradiol secretion by the testis. However, the degree of breast development does not correlate with the rate of estrogen production, leading us to propose that feminization is a function of the degree of androgen resistance as well as the rate of estrogen formation. To test this hypothesis we measured estrogen and androgen formation in two brothers with perineoscrotal hypospadias and severe gynecomastia (the Reifenstein phenotype) due to a mutation that impairs androgen receptor function. Rates of estradiol production (60 and 70 μg/day) were elevated, but were not as high as in previously studied men with a similar phenotype. We conclude that the variable degree of feminization in this disorder cannot be explained by androgen resistance alone.

Original languageEnglish (US)
Pages (from-to)247-251
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume71
Issue number1
StatePublished - Jul 1990

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Androgen-Insensitivity Syndrome
Feminization
Androgens
Gynecomastia
Siblings
Estrogens
Androgen Receptors
Phenotype
Estradiol
Virilism
Hypospadias
Defects
Testis
Breast
Mutation

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Guerami, A., Griffin III, J., Kovacs, W. J., Grino, P. B., Macdonald, P. C., & Wilson, J. D. (1990). Estrogen and androgen production rates in two brothers with reifenstein syndrome. Journal of Clinical Endocrinology and Metabolism, 71(1), 247-251.

Estrogen and androgen production rates in two brothers with reifenstein syndrome. / Guerami, Alireza; Griffin III, Jim; Kovacs, William J.; Grino, Placido B.; Macdonald, Paul C.; Wilson, Jean D.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 71, No. 1, 07.1990, p. 247-251.

Research output: Contribution to journalArticle

Guerami, A, Griffin III, J, Kovacs, WJ, Grino, PB, Macdonald, PC & Wilson, JD 1990, 'Estrogen and androgen production rates in two brothers with reifenstein syndrome', Journal of Clinical Endocrinology and Metabolism, vol. 71, no. 1, pp. 247-251.
Guerami, Alireza ; Griffin III, Jim ; Kovacs, William J. ; Grino, Placido B. ; Macdonald, Paul C. ; Wilson, Jean D. / Estrogen and androgen production rates in two brothers with reifenstein syndrome. In: Journal of Clinical Endocrinology and Metabolism. 1990 ; Vol. 71, No. 1. pp. 247-251.
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