Östrogenwirkungen im gehirn

Translated title of the contribution: Estrogen effects on the brain

Research output: Contribution to journalArticle

Abstract

Estradiol is not only synthesized in the gonads but also in the brain. As a neurosteroid estradiol fulfills a variety of functions in the brain, presumably in conjunction with estrogen derived from the gonads. Its effects are classically mediated by genomic estrogen receptors (isoforms α and β). However, non-genomic estrogen effects, which may be mediated by membrane estrogen receptors, have also been described. Neuroprotective effects of estrogens are observed after cell damage in response to various insults. A variety of neurotransmitters, such as acetylcholine and serotonin, are affected by estradiol. Furthermore, synaptic plasticity of the hippocampus is regulated by the steroid. Estrogen synthesis and signaling targets may be of therapeutic use with regard to neurological diseases, i.e., Alzheimer's disease, Parkinson's disease, and depression.

Original languageGerman
Pages (from-to)6-11
Number of pages6
JournalGynakologische Endokrinologie
Volume4
Issue number1
DOIs
StatePublished - Feb 2006

Fingerprint

Estrogens
Estradiol
Brain
Gonads
Estrogen Receptors
Neurotransmitter Agents
Neuronal Plasticity
Neuroprotective Agents
Therapeutic Uses
Acetylcholine
Parkinson Disease
Hippocampus
Serotonin
Alzheimer Disease
Protein Isoforms
Steroids
Depression
Membranes

Keywords

  • Estrogen
  • Hippocampus
  • Neurodegenerative disease
  • Neuroprotection
  • Neurosteroid

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Endocrinology, Diabetes and Metabolism

Cite this

Östrogenwirkungen im gehirn. / Prange-Kiel, J.

In: Gynakologische Endokrinologie, Vol. 4, No. 1, 02.2006, p. 6-11.

Research output: Contribution to journalArticle

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