Abstract
Estrogen receptor-binding affinity and estrogenic and antie strogenic activity have been evaluated for tamoxifen analogs substituted with various side chains. Antagonist activity of the compounds of this series appears to be dependent on the presence of the β-tert-aminoethoxy moiety. The results also indicate that the dissociation of these compounds from the estrogen receptor-binding site at 25 C is very slow.
Original language | English (US) |
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Pages (from-to) | 486-489 |
Number of pages | 4 |
Journal | Steroids |
Volume | 56 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1991 |
Keywords
- estrogen agonist activity
- estrogen antagonist activity
- estrogen receptor
- relative binding affinity
- steroid
- tamoxifen
- tamoxifen analog
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Endocrinology
- Pharmacology
- Clinical Biochemistry
- Organic Chemistry