Estrogen receptor-binding affinity of tamoxifen analogs with various side chains and their biologic profile in immature rat uterus

Anil K. Agarwal, Rajeshwar D. Bindal

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Estrogen receptor-binding affinity and estrogenic and antie strogenic activity have been evaluated for tamoxifen analogs substituted with various side chains. Antagonist activity of the compounds of this series appears to be dependent on the presence of the β-tert-aminoethoxy moiety. The results also indicate that the dissociation of these compounds from the estrogen receptor-binding site at 25 C is very slow.

Original languageEnglish (US)
Pages (from-to)486-489
Number of pages4
JournalSteroids
Volume56
Issue number9
DOIs
StatePublished - Sep 1991

Keywords

  • estrogen agonist activity
  • estrogen antagonist activity
  • estrogen receptor
  • relative binding affinity
  • steroid
  • tamoxifen
  • tamoxifen analog

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

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