Estrogen-regulated miRNA-27b is altered by bisphenol A in human endometrial stromal cells

Beverly G. Reed, Samir Babayev M.D., Lucy X. Chen, Bruce R Carr, Ruth A Word, Patricia T. Jimenez

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

MicroRNAs (miRs) are small molecules important for regulation of transcription and translation. The objective was to identify hormonally regulated miRs in human endometrial stromal cells and to determine the impact of the endocrine disruptor, bisphenol A (BPA), on those miRs. miR microarray analysis and multiple confirmatory cell preparations treated with 17β-estradiol (E2) and BPA altered miR-27b, let-7c, let-7e and miR-181b. Further, decidualization downregulated miR-27b. VEGFB and VEGFC were validated as targets of miR-27b. Identification of miR-27b target genes suggests that BPA and E2 downregulate miR-27b thereby leading to upregulation of genes important for vascularization and angiogenesis of the endometrium during the menstrual cycle and decidualization.

Original languageEnglish (US)
Pages (from-to)559-567
Number of pages9
JournalReproduction
Volume156
Issue number6
DOIs
StatePublished - 2018

ASJC Scopus subject areas

  • Reproductive Medicine
  • Embryology
  • Endocrinology
  • Obstetrics and Gynecology
  • Cell Biology

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