Östrogene im Gehirn

Translated title of the contribution: Estrogens in the brain

Research output: Contribution to journalArticle

Abstract

In the brain, estrogens have a variety of functions: they regulate sexual differentiation, sexual behavior, and neuronal activity and demonstrate neuroprotective actions. In neuronal tissue, genomic estrogen effects can be distinguished from rapid, non-genomic effects through cellular signal transduction. The genomic effects are mediated by nuclear estrogen receptors (ERα and ERβ), whereas the non-genomic effects are very likely to depend on membranous ERs. Estrogens are synthesized by aromatase, an enzyme that is expressed in various brain regions. A brain-specific promoter regulates the tissue-specific expression of the aromatase gene. The aromatase activity can rapidly be regulated by phosphorylation and is influenced by neuronal activity. Preclinical studies demonstrate the protective effects of estrogens with respect to neurodegenerative diseases, such as stroke. More research will be necessary in order to close the gap between these preclinical results and data from clinical trials and to develop estrogen therapies for neuronal diseases.

Original languageGerman
Pages (from-to)8-13
Number of pages6
JournalGynakologische Endokrinologie
Volume9
Issue number1
DOIs
StatePublished - Feb 2011

Fingerprint

Estrogens
Aromatase
Brain
Sex Differentiation
Sexual Behavior
Estrogen Receptors
Neurodegenerative Diseases
Signal Transduction
Stroke
Phosphorylation
Clinical Trials
Gene Expression
Enzymes
Research
Therapeutics

Keywords

  • Aromatase
  • Brain
  • Estrogens
  • Neuroprotection
  • Stroke

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Östrogene im Gehirn. / Prange-Kiel, J.

In: Gynakologische Endokrinologie, Vol. 9, No. 1, 02.2011, p. 8-13.

Research output: Contribution to journalArticle

@article{d09e35cb67304e019595685e7fe17b47,
title = "{\"O}strogene im Gehirn",
abstract = "In the brain, estrogens have a variety of functions: they regulate sexual differentiation, sexual behavior, and neuronal activity and demonstrate neuroprotective actions. In neuronal tissue, genomic estrogen effects can be distinguished from rapid, non-genomic effects through cellular signal transduction. The genomic effects are mediated by nuclear estrogen receptors (ERα and ERβ), whereas the non-genomic effects are very likely to depend on membranous ERs. Estrogens are synthesized by aromatase, an enzyme that is expressed in various brain regions. A brain-specific promoter regulates the tissue-specific expression of the aromatase gene. The aromatase activity can rapidly be regulated by phosphorylation and is influenced by neuronal activity. Preclinical studies demonstrate the protective effects of estrogens with respect to neurodegenerative diseases, such as stroke. More research will be necessary in order to close the gap between these preclinical results and data from clinical trials and to develop estrogen therapies for neuronal diseases.",
keywords = "Aromatase, Brain, Estrogens, Neuroprotection, Stroke",
author = "J. Prange-Kiel",
year = "2011",
month = "2",
doi = "10.1007/s10304-010-0391-9",
language = "German",
volume = "9",
pages = "8--13",
journal = "Gynakologische Endokrinologie",
issn = "1610-2894",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Östrogene im Gehirn

AU - Prange-Kiel, J.

PY - 2011/2

Y1 - 2011/2

N2 - In the brain, estrogens have a variety of functions: they regulate sexual differentiation, sexual behavior, and neuronal activity and demonstrate neuroprotective actions. In neuronal tissue, genomic estrogen effects can be distinguished from rapid, non-genomic effects through cellular signal transduction. The genomic effects are mediated by nuclear estrogen receptors (ERα and ERβ), whereas the non-genomic effects are very likely to depend on membranous ERs. Estrogens are synthesized by aromatase, an enzyme that is expressed in various brain regions. A brain-specific promoter regulates the tissue-specific expression of the aromatase gene. The aromatase activity can rapidly be regulated by phosphorylation and is influenced by neuronal activity. Preclinical studies demonstrate the protective effects of estrogens with respect to neurodegenerative diseases, such as stroke. More research will be necessary in order to close the gap between these preclinical results and data from clinical trials and to develop estrogen therapies for neuronal diseases.

AB - In the brain, estrogens have a variety of functions: they regulate sexual differentiation, sexual behavior, and neuronal activity and demonstrate neuroprotective actions. In neuronal tissue, genomic estrogen effects can be distinguished from rapid, non-genomic effects through cellular signal transduction. The genomic effects are mediated by nuclear estrogen receptors (ERα and ERβ), whereas the non-genomic effects are very likely to depend on membranous ERs. Estrogens are synthesized by aromatase, an enzyme that is expressed in various brain regions. A brain-specific promoter regulates the tissue-specific expression of the aromatase gene. The aromatase activity can rapidly be regulated by phosphorylation and is influenced by neuronal activity. Preclinical studies demonstrate the protective effects of estrogens with respect to neurodegenerative diseases, such as stroke. More research will be necessary in order to close the gap between these preclinical results and data from clinical trials and to develop estrogen therapies for neuronal diseases.

KW - Aromatase

KW - Brain

KW - Estrogens

KW - Neuroprotection

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=79952993075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952993075&partnerID=8YFLogxK

U2 - 10.1007/s10304-010-0391-9

DO - 10.1007/s10304-010-0391-9

M3 - Article

AN - SCOPUS:79952993075

VL - 9

SP - 8

EP - 13

JO - Gynakologische Endokrinologie

JF - Gynakologische Endokrinologie

SN - 1610-2894

IS - 1

ER -