Ethylene dibromide: effects of paternal exposure on the neurotransmitter enzymes in the developing brain of F1 progeny

Louise L. Hsu, Perrie M. Adams, Donatella Fanini, Marvin S. Legator

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The effects of ethylene dibromide (EDB) exposure to male rats on several neurotransmitter enzymes have been examined in various brain regions of the F1 progeny, from 7 to 90 days of age. The choline acetyltransferase activity was significantly increased at 21 days old, in most brain regions studied in the F1 progeny of the EDB-treated males, but not at 7, 14 or 90 days old. The acetylcholinesterase activity was altered in different brain regions of the F1 progeny of the EDB-exposed males at both 14 and 21 days old but not at 7 or 90 days old. Glutamic acid decarboxylase activity was increased in corpus striatum but decreased in frontal cortex only at 21 days of age. These neurochemical changes in the developing brain of F1 progeny of EDB-treated males at low doses may be associated with behavioral abnormalities observed early in their development.

Original languageEnglish (US)
Pages (from-to)197-203
Number of pages7
JournalMutation Research/Environmental Mutagenesis and Related Subjects
Volume147
Issue number4
DOIs
StatePublished - Aug 1985

ASJC Scopus subject areas

  • Toxicology
  • Genetics

Fingerprint Dive into the research topics of 'Ethylene dibromide: effects of paternal exposure on the neurotransmitter enzymes in the developing brain of F<sub>1</sub> progeny'. Together they form a unique fingerprint.

  • Cite this