Eukaryotic Ribosome Assembly and Export

V. G. Panse, C. S. Weirich

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In eukaryotes, ribosome biogenesis spans three cellular compartments and requires the concerted action of three RNA polymerases, as well as the splicing and nucleocytoplasmic transport machinery. In addition, this process requires >200 trans-acting biogenesis factors, including a range of energy-consuming enzymes and RNA-binding scaffolds that perform both assembly and proofreading functions. Although the mechanisms of ribosome assembly and transport have not yet been fully elucidated, a general framework for this process has emerged from a combination of approaches applied to the organism budding yeast. Here, we review the current state of knowledge of yeast ribosome assembly, quality control, and nuclear export.

Original languageEnglish (US)
Title of host publicationFunctional Cell Biology
PublisherElsevier Inc.
Pages297-306
Number of pages10
Volume3
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
DOIs
StatePublished - Jan 1 2015

Fingerprint

Ribosomes
Cell Nucleus Active Transport
Saccharomycetales
Trans-Activators
DNA-Directed RNA Polymerases
Eukaryota
Quality Control
Yeasts
RNA
Enzymes

Keywords

  • Cytoplasm
  • Large subunit
  • Nuclear export
  • Nucleolus
  • Nucleus
  • Ribosomal protein
  • Ribosomal RNA
  • Ribosome
  • Ribosome biogenesis
  • RNA processing
  • Small subunit

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Panse, V. G., & Weirich, C. S. (2015). Eukaryotic Ribosome Assembly and Export. In Functional Cell Biology (Vol. 3, pp. 297-306). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-394447-4.30040-2

Eukaryotic Ribosome Assembly and Export. / Panse, V. G.; Weirich, C. S.

Functional Cell Biology. Vol. 3 Elsevier Inc., 2015. p. 297-306.

Research output: Chapter in Book/Report/Conference proceedingChapter

Panse, VG & Weirich, CS 2015, Eukaryotic Ribosome Assembly and Export. in Functional Cell Biology. vol. 3, Elsevier Inc., pp. 297-306. https://doi.org/10.1016/B978-0-12-394447-4.30040-2
Panse VG, Weirich CS. Eukaryotic Ribosome Assembly and Export. In Functional Cell Biology. Vol. 3. Elsevier Inc. 2015. p. 297-306 https://doi.org/10.1016/B978-0-12-394447-4.30040-2
Panse, V. G. ; Weirich, C. S. / Eukaryotic Ribosome Assembly and Export. Functional Cell Biology. Vol. 3 Elsevier Inc., 2015. pp. 297-306
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