Eukaryotic Ribosome Assembly and Export

V. G. Panse, C. S. Weirich

Research output: Chapter in Book/Report/Conference proceedingChapter


In eukaryotes, ribosome biogenesis spans three cellular compartments and requires the concerted action of three RNA polymerases, as well as the splicing and nucleocytoplasmic transport machinery. In addition, this process requires >200 trans-acting biogenesis factors, including a range of energy-consuming enzymes and RNA-binding scaffolds that perform both assembly and proofreading functions. Although the mechanisms of ribosome assembly and transport have not yet been fully elucidated, a general framework for this process has emerged from a combination of approaches applied to the organism budding yeast. Here, we review the current state of knowledge of yeast ribosome assembly, quality control, and nuclear export.

Original languageEnglish (US)
Title of host publicationFunctional Cell Biology
PublisherElsevier Inc.
Number of pages10
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
StatePublished - Jan 1 2016


  • Cytoplasm
  • Large subunit
  • Nuclear export
  • Nucleolus
  • Nucleus
  • RNA processing
  • Ribosomal RNA
  • Ribosomal protein
  • Ribosome
  • Ribosome biogenesis
  • Small subunit

ASJC Scopus subject areas

  • Medicine(all)


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