PARACEST redox sensors containing the NAD +/NADH mimic N-methylquinolinium moiety as a redox-active functional group have been designed and synthesized. The Eu 3+ complex with two quinolinium moieties was nearly completely CEST-silent in the oxidized form but was "turned on" upon reduction with β-NADH. The CEST effect of the Eu 3+ complex containing only one quinolinium group was much less redox-responsive but showed an unexpected sensitivity to pH in the physiologically relevant pH range.
ASJC Scopus subject areas
- Colloid and Surface Chemistry