Europium(III) dota-tetraamide complexes as redox-active mri sensors

S. James Ratnakar, Subha Viswanathan, Zoltan Kovacs, Ashish K. Jindal, Kayla N. Green, A. Dean Sherry

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

PARACEST redox sensors containing the NAD +/NADH mimic N-methylquinolinium moiety as a redox-active functional group have been designed and synthesized. The Eu 3+ complex with two quinolinium moieties was nearly completely CEST-silent in the oxidized form but was "turned on" upon reduction with β-NADH. The CEST effect of the Eu 3+ complex containing only one quinolinium group was much less redox-responsive but showed an unexpected sensitivity to pH in the physiologically relevant pH range.

Original languageEnglish (US)
Pages (from-to)5798-5800
Number of pages3
JournalJournal of the American Chemical Society
Volume134
Issue number13
DOIs
Publication statusPublished - Apr 4 2012

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ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

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