TY - GEN
T1 - Evaluating Microelectrode Arrays in Peripheral Nerve Using Micro Computed Tomography
AU - Frederick, Rebecca A.
AU - Margolis, Ryan
AU - Hoyt, Kenneth
AU - Cogan, Stuart F.
N1 - Publisher Copyright:
© 2020 IEEE.
PY - 2020/7
Y1 - 2020/7
N2 - Many advances have been made with imaging of implanted neural devices; however, the ability to image whole nerve samples remains limited. Further, few imaging modalities are well suited for visualizing both whole devices in vivo and individual microelectrodes within a nerve. In this study, we used micro-computed tomography (micro-CT) to evaluate Wireless Floating Microelectrode Arrays (WMFAs) implanted in rat sciatic nerve at the level of whole devices and individual electrodes. WFMAs were also used to track selective recruitment of plantar flexion and dorsiflexion of the rear paw, which was achieved by each implanted device (n=6) during chronic implantation. Evoked limb motion was correlated to end-of-study assessments using micro-CT to visualize electrode locations within the fascicular structure of the sciatic nerve. Results of this study show that micro-CT imaging can provide valuable assessments of microelectrode arrays implanted in peripheral nerves for both whole devices visualized in vivo and individual electrodes visualized in whole nerve tissue samples.Clinical relevance - This work informs the use of micro-computed tomography as a tool for correlating neural device performance with physical attributes of the implant location.
AB - Many advances have been made with imaging of implanted neural devices; however, the ability to image whole nerve samples remains limited. Further, few imaging modalities are well suited for visualizing both whole devices in vivo and individual microelectrodes within a nerve. In this study, we used micro-computed tomography (micro-CT) to evaluate Wireless Floating Microelectrode Arrays (WMFAs) implanted in rat sciatic nerve at the level of whole devices and individual electrodes. WFMAs were also used to track selective recruitment of plantar flexion and dorsiflexion of the rear paw, which was achieved by each implanted device (n=6) during chronic implantation. Evoked limb motion was correlated to end-of-study assessments using micro-CT to visualize electrode locations within the fascicular structure of the sciatic nerve. Results of this study show that micro-CT imaging can provide valuable assessments of microelectrode arrays implanted in peripheral nerves for both whole devices visualized in vivo and individual electrodes visualized in whole nerve tissue samples.Clinical relevance - This work informs the use of micro-computed tomography as a tool for correlating neural device performance with physical attributes of the implant location.
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U2 - 10.1109/EMBC44109.2020.9176598
DO - 10.1109/EMBC44109.2020.9176598
M3 - Conference contribution
C2 - 33018741
AN - SCOPUS:85091013034
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 3432
EP - 3435
BT - 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020
Y2 - 20 July 2020 through 24 July 2020
ER -