Evaluating the role of biomarkers for cardiovascular risk prediction: Focus on CRP, BNP and urinary microalbumin

Abigail May, Thomas J. Wang

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Cardiovascular disease is a significant cause of morbidity and mortality, making cardiovascular prevention an important public health goal. The use of cardiac biomarkers represents a potential, noninvasive method to identify asymptomatic individuals who are most likely to develop cardiovascular disease. Several known biomarkers predict cardiovascular risk above and beyond conventional risk factors. Nonetheless, available evidence suggests that current biomarkers do not have sufficient sensitivity or specificity to justify widespread use for cardiovascular risk prediction. New developments in molecular biology and genetics may allow the identification of additional biomarkers, likely acting via different pathways, to achieve this goal.

Original languageEnglish (US)
Pages (from-to)793-804
Number of pages12
JournalExpert Review of Molecular Diagnostics
Volume7
Issue number6
DOIs
StatePublished - Nov 1 2007
Externally publishedYes

Keywords

  • B-type natriuretic peptide
  • Biomarker
  • C-reactive protein
  • Cardiovascular risk
  • Urinary microalbumin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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