Evaluating tumor-suppressor gene combinations news-and-views

James Kim; John D. Minna

doi:10.1038/s41588-018-0095-y

Evaluating tumor-suppressor gene combinations news-and-views

James Kim, John D. Minna

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

In vivo verification of tumor suppressors and their interactions with each other has required complex experiments. A report in this issue uses a novel CRISPR-Cas9 technology with barcodes to test, in parallel, the tumorigenic potential of functional loss of multiple tumor-suppressor genes in the context of a genetically engineered mouse model of lung adenocarcinoma with mutant Kras.

Original language	English (US)
Pages (from-to)	480-482
Number of pages	3
Journal	Nature genetics
Volume	50
Issue number	4
DOIs	https://doi.org/10.1038/s41588-018-0095-y
State	Published - Apr 1 2018

ASJC Scopus subject areas

Genetics

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10.1038/s41588-018-0095-y

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abstract = "In vivo verification of tumor suppressors and their interactions with each other has required complex experiments. A report in this issue uses a novel CRISPR-Cas9 technology with barcodes to test, in parallel, the tumorigenic potential of functional loss of multiple tumor-suppressor genes in the context of a genetically engineered mouse model of lung adenocarcinoma with mutant Kras.",

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AB - In vivo verification of tumor suppressors and their interactions with each other has required complex experiments. A report in this issue uses a novel CRISPR-Cas9 technology with barcodes to test, in parallel, the tumorigenic potential of functional loss of multiple tumor-suppressor genes in the context of a genetically engineered mouse model of lung adenocarcinoma with mutant Kras.

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Evaluating tumor-suppressor gene combinations news-and-views

Abstract

ASJC Scopus subject areas

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