Abstract
An observational study was conducted in 164 patients with resistant or difficult-to-control hypertension. Treatment was adjusted to achieve blood pressure recommendations from the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7). Patients were mostly male (95.73%) and African American (86.595) and had an average age of 63.68 years. Comorbidities included diabetes (42.07%) and chronic kidney disease, with an average estimated glomerular filtration rate of 83.55 mL/min/ 1.73 m2. At the time of referral, average blood pressure was 160/87mm Hg. The average number of antihypertensive medications per patient at baseline was 3.43, which increased to 4.06 and 4.18 at 3 and 6 months, respectively (P≤.0008), with about 80% of patients receiving a diuretic prior to intervention. Blood pressure decreased to 135.55/74.55 and 137.62/74.03mm Hg at 3 and 6months, respectively (P<.0001). By month 6, the blood pressure goal was reached in 45.10% of patients. At months 3 and 6, 100% of patients were now receiving a diuretic. The average estimated glomerular filtration rate at month 6 was 79.36mL/min/ 1.73 m2 (P=NS). Patients referred for resistant or difficult-to-control hypertension may be controlled by making targeted adjustments to their medical regimen.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 837-843 |
| Number of pages | 7 |
| Journal | Journal of Clinical Hypertension |
| Volume | 10 |
| Issue number | 11 |
| DOIs | |
| State | Published - Dec 1 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Cardiology and Cardiovascular Medicine
Cite this
Evaluation and treatment of resistant or difficult-to-control hypertension. / Wojciechowski, David; Papademetriou, Vasilios; Faselis, Charles; Fletcher, Ross.
In: Journal of Clinical Hypertension, Vol. 10, No. 11, 01.12.2008, p. 837-843.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Evaluation and treatment of resistant or difficult-to-control hypertension
AU - Wojciechowski, David
AU - Papademetriou, Vasilios
AU - Faselis, Charles
AU - Fletcher, Ross
PY - 2008/12/1
Y1 - 2008/12/1
N2 - An observational study was conducted in 164 patients with resistant or difficult-to-control hypertension. Treatment was adjusted to achieve blood pressure recommendations from the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7). Patients were mostly male (95.73%) and African American (86.595) and had an average age of 63.68 years. Comorbidities included diabetes (42.07%) and chronic kidney disease, with an average estimated glomerular filtration rate of 83.55 mL/min/ 1.73 m2. At the time of referral, average blood pressure was 160/87mm Hg. The average number of antihypertensive medications per patient at baseline was 3.43, which increased to 4.06 and 4.18 at 3 and 6 months, respectively (P≤.0008), with about 80% of patients receiving a diuretic prior to intervention. Blood pressure decreased to 135.55/74.55 and 137.62/74.03mm Hg at 3 and 6months, respectively (P<.0001). By month 6, the blood pressure goal was reached in 45.10% of patients. At months 3 and 6, 100% of patients were now receiving a diuretic. The average estimated glomerular filtration rate at month 6 was 79.36mL/min/ 1.73 m2 (P=NS). Patients referred for resistant or difficult-to-control hypertension may be controlled by making targeted adjustments to their medical regimen.
AB - An observational study was conducted in 164 patients with resistant or difficult-to-control hypertension. Treatment was adjusted to achieve blood pressure recommendations from the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7). Patients were mostly male (95.73%) and African American (86.595) and had an average age of 63.68 years. Comorbidities included diabetes (42.07%) and chronic kidney disease, with an average estimated glomerular filtration rate of 83.55 mL/min/ 1.73 m2. At the time of referral, average blood pressure was 160/87mm Hg. The average number of antihypertensive medications per patient at baseline was 3.43, which increased to 4.06 and 4.18 at 3 and 6 months, respectively (P≤.0008), with about 80% of patients receiving a diuretic prior to intervention. Blood pressure decreased to 135.55/74.55 and 137.62/74.03mm Hg at 3 and 6months, respectively (P<.0001). By month 6, the blood pressure goal was reached in 45.10% of patients. At months 3 and 6, 100% of patients were now receiving a diuretic. The average estimated glomerular filtration rate at month 6 was 79.36mL/min/ 1.73 m2 (P=NS). Patients referred for resistant or difficult-to-control hypertension may be controlled by making targeted adjustments to their medical regimen.
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U2 - 10.1111/j.1751-7176.2008.00037.x
DO - 10.1111/j.1751-7176.2008.00037.x
M3 - Article
C2 - 19128272
AN - SCOPUS:60749118941
VL - 10
SP - 837
EP - 843
JO - Journal of Clinical Hypertension
JF - Journal of Clinical Hypertension
SN - 1524-6175
IS - 11
ER -