Evaluation of a microfocused ultrasound system for improving skin laxity and tightening in the lower face

Georgette Oni, Ron Hoxworth, Sumeet Teotia, Spencer Brown, Jeffrey M. Kenkel

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

BACKGROUND: The Ulthera System (Ulthera, Inc, Mesa, Arizona) employs microfocused ultrasound to cause discrete focal heating of the dermis and stimulate neocollagenesis and elastin remodeling.

OBJECTIVES: The authors investigated tightening and lifting of cheek tissue, improvement in jawline definition, and reduction in submental skin laxity in patients treated with the Ulthera System.

METHODS: A total of 103 adults were enrolled in this prospective nonrandomized clinical trial. Three-dimensional photographs obtained at baseline and 3 months posttreatment were assessed qualitatively by 3 blinded reviewers and quantitatively with AutoCAD software (Informer Technologies, Redwood City, California). The relationship between outcomes and body mass index (BMI) was examined as well. Patients rated pain during the procedure and provided subjective assessment of their outcome at 90 days. Adverse events were documented.

RESULTS: Ninety-three patients were evaluated. Blinded reviewers observed improvement in skin laxity in 58.1% of patients. During quantitative assessments, overall improvement in skin laxity was noted in 63.6% of evaluated patients. No change was detected in 54.5% of patients whose BMI exceeded 30 kg/m2 or in 12.2% of patients whose BMI was ≤30 kg/m2. At day 90, 65.6% of patients perceived improvement in the skin laxity of the lower half of their face/neck. The average procedural pain scores for the cheek, submental, and submandibular regions were 5.68, 6.09, and 6.53, respectively. Wheals, which resolved without intervention or long-term sequelae, were reported for 3 patients.

CONCLUSIONS: To the authors' knowledge, this is the largest clinical study of the effectiveness of the Ulthera System for rejuvenation of the lower face. At day 90, improvements were reported by two-thirds of patients and by nearly 60% of blinded reviewers. Outcomes were better in patients with BMI≤30 kg/m2.2.

Original languageEnglish (US)
Pages (from-to)1099-1110
Number of pages12
JournalAesthetic surgery journal / the American Society for Aesthetic Plastic surgery
Volume34
Issue number7
DOIs
StatePublished - Sep 1 2014

Fingerprint

Skin
Body Mass Index
Cheek
Sequoia
Rejuvenation
Pain
Elastin
Dermis
Heating
Neck
Software
Outcome Assessment (Health Care)
Technology

Keywords

  • facial rejuvenation
  • microfocused ultrasound
  • nonsurgical skin rejuvenation
  • Ulthera

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{25a5c8ee07544b57920ea155ab242f61,
title = "Evaluation of a microfocused ultrasound system for improving skin laxity and tightening in the lower face",
abstract = "BACKGROUND: The Ulthera System (Ulthera, Inc, Mesa, Arizona) employs microfocused ultrasound to cause discrete focal heating of the dermis and stimulate neocollagenesis and elastin remodeling.OBJECTIVES: The authors investigated tightening and lifting of cheek tissue, improvement in jawline definition, and reduction in submental skin laxity in patients treated with the Ulthera System.METHODS: A total of 103 adults were enrolled in this prospective nonrandomized clinical trial. Three-dimensional photographs obtained at baseline and 3 months posttreatment were assessed qualitatively by 3 blinded reviewers and quantitatively with AutoCAD software (Informer Technologies, Redwood City, California). The relationship between outcomes and body mass index (BMI) was examined as well. Patients rated pain during the procedure and provided subjective assessment of their outcome at 90 days. Adverse events were documented.RESULTS: Ninety-three patients were evaluated. Blinded reviewers observed improvement in skin laxity in 58.1{\%} of patients. During quantitative assessments, overall improvement in skin laxity was noted in 63.6{\%} of evaluated patients. No change was detected in 54.5{\%} of patients whose BMI exceeded 30 kg/m2 or in 12.2{\%} of patients whose BMI was ≤30 kg/m2. At day 90, 65.6{\%} of patients perceived improvement in the skin laxity of the lower half of their face/neck. The average procedural pain scores for the cheek, submental, and submandibular regions were 5.68, 6.09, and 6.53, respectively. Wheals, which resolved without intervention or long-term sequelae, were reported for 3 patients.CONCLUSIONS: To the authors' knowledge, this is the largest clinical study of the effectiveness of the Ulthera System for rejuvenation of the lower face. At day 90, improvements were reported by two-thirds of patients and by nearly 60{\%} of blinded reviewers. Outcomes were better in patients with BMI≤30 kg/m2.2.",
keywords = "facial rejuvenation, microfocused ultrasound, nonsurgical skin rejuvenation, Ulthera",
author = "Georgette Oni and Ron Hoxworth and Sumeet Teotia and Spencer Brown and Kenkel, {Jeffrey M.}",
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T1 - Evaluation of a microfocused ultrasound system for improving skin laxity and tightening in the lower face

AU - Oni, Georgette

AU - Hoxworth, Ron

AU - Teotia, Sumeet

AU - Brown, Spencer

AU - Kenkel, Jeffrey M.

PY - 2014/9/1

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N2 - BACKGROUND: The Ulthera System (Ulthera, Inc, Mesa, Arizona) employs microfocused ultrasound to cause discrete focal heating of the dermis and stimulate neocollagenesis and elastin remodeling.OBJECTIVES: The authors investigated tightening and lifting of cheek tissue, improvement in jawline definition, and reduction in submental skin laxity in patients treated with the Ulthera System.METHODS: A total of 103 adults were enrolled in this prospective nonrandomized clinical trial. Three-dimensional photographs obtained at baseline and 3 months posttreatment were assessed qualitatively by 3 blinded reviewers and quantitatively with AutoCAD software (Informer Technologies, Redwood City, California). The relationship between outcomes and body mass index (BMI) was examined as well. Patients rated pain during the procedure and provided subjective assessment of their outcome at 90 days. Adverse events were documented.RESULTS: Ninety-three patients were evaluated. Blinded reviewers observed improvement in skin laxity in 58.1% of patients. During quantitative assessments, overall improvement in skin laxity was noted in 63.6% of evaluated patients. No change was detected in 54.5% of patients whose BMI exceeded 30 kg/m2 or in 12.2% of patients whose BMI was ≤30 kg/m2. At day 90, 65.6% of patients perceived improvement in the skin laxity of the lower half of their face/neck. The average procedural pain scores for the cheek, submental, and submandibular regions were 5.68, 6.09, and 6.53, respectively. Wheals, which resolved without intervention or long-term sequelae, were reported for 3 patients.CONCLUSIONS: To the authors' knowledge, this is the largest clinical study of the effectiveness of the Ulthera System for rejuvenation of the lower face. At day 90, improvements were reported by two-thirds of patients and by nearly 60% of blinded reviewers. Outcomes were better in patients with BMI≤30 kg/m2.2.

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