Evaluation of C1q genomic region in minority racial groups of lupus

B. Namjou, C. Gray-McGuire, A. L. Sestak, G. S. Gilkeson, C. O. Jacob, J. T. Merrill, J. A. James, E. K. Wakeland, Q. Z. Li, C. D. Langefeld, J. Divers, J. Ziegler, K. L. Moser, J. A. Kelly, K. M. Kaufman, J. B. Harley

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Abstract

Complement cascade plasma proteins play a complex role in the etiopathogenesis of systemic lupus erythematosus (SLE). Hereditary C1q deficiency has been strongly related to SLE; however, there are very few published SLE studies that evaluate the polymorphisms of genes encoding for C1q (A, B and C). In this study, we evaluated 17 single nucleotide polymorphisms (SNPs) across 37 kb of C1QA, C1QB and C1QC in a lupus cohort of individuals of the African-American and Hispanic origin. In a case-only analysis, a significant association at multiple SNPs in the C1QA gene was detected in African Americans with kidney nephritis (best P = 4.91 × 10-6). In addition, C1QA was associated with SLE in African Americans with a lack of nephritis and accompanying photosensitivity when compared with that in normal controls (P = 6.80 × 10-6). A similar trend was observed in the Hispanic subjects (P = 0.003). Quantitative analysis showed that some SNPs in C1q genes might be correlated with C3 complement levels in an additive model among African Americans (best P = 0.0001). The C1QA gene is associated with subphenotypes of lupus in the African-American and Hispanic subjects. Further studies with higher SNP densities in this region and other complement components are necessary to elucidate the complex genetics and phenotypic interactions between complement components and SLE.

Original languageEnglish (US)
Pages (from-to)517-524
Number of pages8
JournalGenes and Immunity
Volume10
Issue number5
DOIs
StatePublished - 2009

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Minority Groups
African Americans
Systemic Lupus Erythematosus
Single Nucleotide Polymorphism
Hispanic Americans
Nephritis
Genes
Complement C3
Blood Proteins
Kidney

ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics

Cite this

Namjou, B., Gray-McGuire, C., Sestak, A. L., Gilkeson, G. S., Jacob, C. O., Merrill, J. T., ... Harley, J. B. (2009). Evaluation of C1q genomic region in minority racial groups of lupus. Genes and Immunity, 10(5), 517-524. https://doi.org/10.1038/gene.2009.33

Evaluation of C1q genomic region in minority racial groups of lupus. / Namjou, B.; Gray-McGuire, C.; Sestak, A. L.; Gilkeson, G. S.; Jacob, C. O.; Merrill, J. T.; James, J. A.; Wakeland, E. K.; Li, Q. Z.; Langefeld, C. D.; Divers, J.; Ziegler, J.; Moser, K. L.; Kelly, J. A.; Kaufman, K. M.; Harley, J. B.

In: Genes and Immunity, Vol. 10, No. 5, 2009, p. 517-524.

Research output: Contribution to journalArticle

Namjou, B, Gray-McGuire, C, Sestak, AL, Gilkeson, GS, Jacob, CO, Merrill, JT, James, JA, Wakeland, EK, Li, QZ, Langefeld, CD, Divers, J, Ziegler, J, Moser, KL, Kelly, JA, Kaufman, KM & Harley, JB 2009, 'Evaluation of C1q genomic region in minority racial groups of lupus', Genes and Immunity, vol. 10, no. 5, pp. 517-524. https://doi.org/10.1038/gene.2009.33
Namjou B, Gray-McGuire C, Sestak AL, Gilkeson GS, Jacob CO, Merrill JT et al. Evaluation of C1q genomic region in minority racial groups of lupus. Genes and Immunity. 2009;10(5):517-524. https://doi.org/10.1038/gene.2009.33
Namjou, B. ; Gray-McGuire, C. ; Sestak, A. L. ; Gilkeson, G. S. ; Jacob, C. O. ; Merrill, J. T. ; James, J. A. ; Wakeland, E. K. ; Li, Q. Z. ; Langefeld, C. D. ; Divers, J. ; Ziegler, J. ; Moser, K. L. ; Kelly, J. A. ; Kaufman, K. M. ; Harley, J. B. / Evaluation of C1q genomic region in minority racial groups of lupus. In: Genes and Immunity. 2009 ; Vol. 10, No. 5. pp. 517-524.
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