Evaluation of early second trimester maternal serum creatine kinase isoenzyme bb as a marker of poor pregnancy outcome

Chuka B. Jenkins, Alessandro Ghidini, Catherine Y. Spong, Gary S. Eglinton, John C. Pezzullo, Maria Michejda

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We hypothesized that maternal serum levels of the isoenzyme creatine kinase (CK)-BB which is highly expressed in the placenta, may be elevated during the early second trimester in gestations destined to deliver prematurely or of a small-for-gestational-age infant (birthweight below 10th percentile). To test this hypothesis, we compared maternal serum CK-BB levels and percentage of CK-BB over total CK, in 69 normal pregnancies (delivering at term of appropriate-for-gestational-age infants) with those of 25 cases complicated by preterm delivery at < 34 weeks (n=14), of a small-for-gestational-age infant (n=8), or both (n=3). No differences were present in maternal serum CK BB levels between normal and complicated pregnancies. Moreover, no correlation was found between gestational age at delivery and CK BB levels (r=0.03; p=0.7).

Original languageEnglish (US)
Pages (from-to)356-359
Number of pages4
JournalFetal Diagnosis and Therapy
Volume12
Issue number6
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Keywords

  • Creatine kinase
  • Pregnancy complications
  • Tissue ischemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynecology

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