Evaluation of neoadjuvant chemotherapeutic response of locally advanced breast cancer by magnetic resonance imaging

Dana C. Abraham, Ronald C. Jones, Stephen E. Jones, J. Harold Cheek, George N. Peters, Sally M. Knox, Michael D. Grant, David W. Hampe, Daniel A. Savino, Steven E. Harms

Research output: Contribution to journalArticle

229 Scopus citations

Abstract

BACKGROUND. The implementation of new treatment protocols for locally advanced breast cancer is currently limited by inaccurate evaluation of response to neoadjuvant chemotherapy. A recently developed dedicated breast magnetic resonance imaging (MRI) method (RODEO MRI) was evaluated as a tool for determining tumor response and extent of residual disease after neoadjuvant chemotherapy. METHODS. Thirty-nine patients with Stage II, III, or IV breast carcinoma were prospectively evaluated prior to and following neoadjuvant chemotherapy by MRI, physical examination, and mammography. Assessment of response determined by the three methods was compared. In addition, detailed pathologic correlation of residual disease was determined by serial sectioning of 31 mastectomy specimens from 30 patients. Nine patients had breast conservation, and were included in the response evaluation only. Estimates of tumor response were made by both surgical and medical oncologists. Independent interpretations of MRI studies without knowledge of clinical response were made by three radiologists. RESULTS. The surgical oncologists assessed complete response (CR), partial response (PR), and no response (NR) in 11, 22, and 7 cases, respectively. The medical oncologists assessed CR, PR, and NR in 12, 21, and 7 cases, respectively. The surgical and medical oncologists' clinical assessment of response agreed with the results of MRI in 52% and 55% of cases, respectively, and with each other in 30 of 40 cases (75%). Mammography correlated with MRI response in only 52% of cases. However, MRI accurately predicted the pathologic determination of residual disease in 30 of 31 cases (97%). There was no disagreement in the assessments of residual disease or response among the three radiologists. CONCLUSIONS. RODEO breast MRI accurately estimates residual disease after induction chemotherapy. It assesses response to neoadjuvant chemotherapy better than traditional methods of physical examination or mammography. The information obtained from this MRI technique may be used as an objective tool during clinical trials, and to select patients better for breast conservation after neoadjuvant chemotherapy for locally advanced disease.

Original languageEnglish (US)
Pages (from-to)91-100
Number of pages10
JournalCancer
Volume78
Issue number1
DOIs
StatePublished - Jul 1 1996

Keywords

  • breast
  • breast neoplasms
  • chemotherapy
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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