Evaluation of new anti-infective drugs for the treatment of acute suppurative arthritis in children

J. D. Nelson, C. Norden, J. T. Mader, G. B. Calandra

Research output: Contribution to journalArticle

4 Scopus citations


Diagnostic criteria for bacterial suppurative arthritis include the demonstration of an inflammatory exudate by aspiration of synovial fluid and the isolation of bacteria from cultures of synovial fluid and/or blood. Clinical manifestations include joint effusion, swelling, tenderness, and pain, with or without redness of the overlying skin. Management consists of antimicrobial therapy, measures designed to relieve symptoms, surgical drainage of infected fluid, and physical therapy. Studies of new anti-infective therapy should be limited to cases of bacterial origin. Prospective, randomized, double-blind or evaluator-blinded, active-control comparative clinical trials should be performed. Clinical response is characterized as success (cure), failure, or indeterminate outcome. The most common successful microbiological outcome is presumptive eradication. Follow-up should continue for 1 year before the final assessment.

Original languageEnglish (US)
Pages (from-to)S172-S176
JournalClinical Infectious Diseases
StatePublished - Nov 1992


ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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