Evaluation of ocular surface inflammation in the presence of dry eye and allergic conjunctival disease

Michael E. Stern; Karyn F. Siemasko; Jianping Gao; Margarita Calonge; Jerry Y. Niederkorn; Stephen C. Pflugfelder

Evaluation of ocular surface inflammation in the presence of dry eye and allergic conjunctival disease

Michael E. Stern, Karyn F. Siemasko, Jianping Gao, Margarita Calonge, Jerry Y. Niederkorn, Stephen C. Pflugfelder

Research output: Contribution to journal › Article › peer-review

Abstract

The ocular inflammatory diseases dry eye and allergic conjunctivitis are mediated by CD4+ T cells. Th1 cells secrete interferon (IFN)-γ and are implicated in mediating the disease process in dry eye. Allergic conjunctivitis has been classically defined as a Th2 disease because of the predominance of Th2 cytokines interleukin (IL)-4 and IL-13. A multi-hit antigen challenge mouse model of allergic conjunctivitis provides evidence that IFN-γ, a Th1 cytokine, acts as an endothelium gatekeeper by regulating endothelial expression of vascular adhesion molecule-1 required for inflammatory conjunctival cell infiltration. Current research encourages an in-depth evaluation of the exact role Th1 and Th2 cells play in ocular inflammation.

Original language	English (US)
Pages (from-to)	S161-S164
Journal	Ocular Surface
Volume	3
Issue number	4
State	Published - Oct 1 2005

Keywords

Allergic conjunctivitis
Dry eye
Inflammation
Ocular surface
Th1
Th2

ASJC Scopus subject areas

Ophthalmology

Cite this

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title = "Evaluation of ocular surface inflammation in the presence of dry eye and allergic conjunctival disease",

abstract = "The ocular inflammatory diseases dry eye and allergic conjunctivitis are mediated by CD4+ T cells. Th1 cells secrete interferon (IFN)-γ and are implicated in mediating the disease process in dry eye. Allergic conjunctivitis has been classically defined as a Th2 disease because of the predominance of Th2 cytokines interleukin (IL)-4 and IL-13. A multi-hit antigen challenge mouse model of allergic conjunctivitis provides evidence that IFN-γ, a Th1 cytokine, acts as an endothelium gatekeeper by regulating endothelial expression of vascular adhesion molecule-1 required for inflammatory conjunctival cell infiltration. Current research encourages an in-depth evaluation of the exact role Th1 and Th2 cells play in ocular inflammation.",

keywords = "Allergic conjunctivitis, Dry eye, Inflammation, Ocular surface, Th1, Th2",

author = "Stern, {Michael E.} and Siemasko, {Karyn F.} and Jianping Gao and Margarita Calonge and Niederkorn, {Jerry Y.} and Pflugfelder, {Stephen C.}",

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T1 - Evaluation of ocular surface inflammation in the presence of dry eye and allergic conjunctival disease

AU - Stern, Michael E.

AU - Siemasko, Karyn F.

AU - Gao, Jianping

AU - Calonge, Margarita

AU - Niederkorn, Jerry Y.

AU - Pflugfelder, Stephen C.

PY - 2005/10/1

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N2 - The ocular inflammatory diseases dry eye and allergic conjunctivitis are mediated by CD4+ T cells. Th1 cells secrete interferon (IFN)-γ and are implicated in mediating the disease process in dry eye. Allergic conjunctivitis has been classically defined as a Th2 disease because of the predominance of Th2 cytokines interleukin (IL)-4 and IL-13. A multi-hit antigen challenge mouse model of allergic conjunctivitis provides evidence that IFN-γ, a Th1 cytokine, acts as an endothelium gatekeeper by regulating endothelial expression of vascular adhesion molecule-1 required for inflammatory conjunctival cell infiltration. Current research encourages an in-depth evaluation of the exact role Th1 and Th2 cells play in ocular inflammation.

AB - The ocular inflammatory diseases dry eye and allergic conjunctivitis are mediated by CD4+ T cells. Th1 cells secrete interferon (IFN)-γ and are implicated in mediating the disease process in dry eye. Allergic conjunctivitis has been classically defined as a Th2 disease because of the predominance of Th2 cytokines interleukin (IL)-4 and IL-13. A multi-hit antigen challenge mouse model of allergic conjunctivitis provides evidence that IFN-γ, a Th1 cytokine, acts as an endothelium gatekeeper by regulating endothelial expression of vascular adhesion molecule-1 required for inflammatory conjunctival cell infiltration. Current research encourages an in-depth evaluation of the exact role Th1 and Th2 cells play in ocular inflammation.

KW - Allergic conjunctivitis

KW - Dry eye

KW - Inflammation

KW - Ocular surface

KW - Th1

KW - Th2

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Evaluation of ocular surface inflammation in the presence of dry eye and allergic conjunctival disease

Abstract

Keywords

ASJC Scopus subject areas

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