Evaluation of ocular surface inflammation in the presence of dry eye and allergic conjunctival disease

Michael E. Stern, Karyn F. Siemasko, Jianping Gao, Margarita Calonge, Jerry Y. Niederkorn, Stephen C. Pflugfelder

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The ocular inflammatory diseases dry eye and allergic conjunctivitis are mediated by CD4+ T cells. Th1 cells secrete interferon (IFN)-γ and are implicated in mediating the disease process in dry eye. Allergic conjunctivitis has been classically defined as a Th2 disease because of the predominance of Th2 cytokines interleukin (IL)-4 and IL-13. A multi-hit antigen challenge mouse model of allergic conjunctivitis provides evidence that IFN-γ, a Th1 cytokine, acts as an endothelium gatekeeper by regulating endothelial expression of vascular adhesion molecule-1 required for inflammatory conjunctival cell infiltration. Current research encourages an in-depth evaluation of the exact role Th1 and Th2 cells play in ocular inflammation.

Original languageEnglish (US)
Pages (from-to)S161-S164
JournalOcular Surface
Volume3
Issue number4
StatePublished - Oct 1 2005

Keywords

  • Allergic conjunctivitis
  • Dry eye
  • Inflammation
  • Ocular surface
  • Th1
  • Th2

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'Evaluation of ocular surface inflammation in the presence of dry eye and allergic conjunctival disease'. Together they form a unique fingerprint.

  • Cite this

    Stern, M. E., Siemasko, K. F., Gao, J., Calonge, M., Niederkorn, J. Y., & Pflugfelder, S. C. (2005). Evaluation of ocular surface inflammation in the presence of dry eye and allergic conjunctival disease. Ocular Surface, 3(4), S161-S164.