TY - JOUR
T1 - Evaluation of oxidative stress status and antioxidant capacity in patients with renal cell carcinoma
AU - Aldemir, Mustafa
AU - Karaguzel, Ersagun
AU - Okulu, Emrah
AU - Gudeloglu, Ahmet
AU - Ener, Kemal
AU - Ozayar, Asim
AU - Erel, Ozcan
N1 - Publisher Copyright:
© 2015, Polish Urological Association. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Introduction We evaluated and compared the serum oxidative stress and antioxidant enzymes in patients with renal cell carcinoma (RCC) and the control group. Material and methods The prospective study consisted of 97 patients with RCC (Group 1) and 80 age and sex matched healthy volunteers (Group 2). Group 1 and 2 were compared concerning serum mean total oxidant status (TOS), total antioxidant capacity (TAC), paraoxonase-1 (PON-1), arylesterase, total thiol, catalase (CAT), myeloperoxidase (MPO) and ceruloplasmin. Results Patients’ mean age was 58.5 ±12.3 and 56.9 ±15.8 years, respectively, in Group 1 and 2. No statistically significant differences were detected between the groups in terms of oxidative stress parameters and antioxidant capacity measured in the serum of patients including, TOS, TAC, PON1, arylesterase, total thiol, CAT, MPO, and ceruloplasmin levels (p >0.05 for all parameters). The PON-1 value was significantly higher in patients with pT1 stage than pT3 stage (p = 0.007). The arylesterase value was significantly higher in patients with Fuhrman’s nuclear grade 3 than grade 2 (p = 0.035). There was no correlation between these parameters level and Fuhrman’s nuclear grade, stage, or histopathological tumor type. Conclusions Our results demonstrated that evaluation of these parameters in the serum of patients with localized RCC may not be used as a marker to discriminate between patients with RCC and healthy people.
AB - Introduction We evaluated and compared the serum oxidative stress and antioxidant enzymes in patients with renal cell carcinoma (RCC) and the control group. Material and methods The prospective study consisted of 97 patients with RCC (Group 1) and 80 age and sex matched healthy volunteers (Group 2). Group 1 and 2 were compared concerning serum mean total oxidant status (TOS), total antioxidant capacity (TAC), paraoxonase-1 (PON-1), arylesterase, total thiol, catalase (CAT), myeloperoxidase (MPO) and ceruloplasmin. Results Patients’ mean age was 58.5 ±12.3 and 56.9 ±15.8 years, respectively, in Group 1 and 2. No statistically significant differences were detected between the groups in terms of oxidative stress parameters and antioxidant capacity measured in the serum of patients including, TOS, TAC, PON1, arylesterase, total thiol, CAT, MPO, and ceruloplasmin levels (p >0.05 for all parameters). The PON-1 value was significantly higher in patients with pT1 stage than pT3 stage (p = 0.007). The arylesterase value was significantly higher in patients with Fuhrman’s nuclear grade 3 than grade 2 (p = 0.035). There was no correlation between these parameters level and Fuhrman’s nuclear grade, stage, or histopathological tumor type. Conclusions Our results demonstrated that evaluation of these parameters in the serum of patients with localized RCC may not be used as a marker to discriminate between patients with RCC and healthy people.
KW - Antioxidant capacity
KW - Oxidative stress
KW - Renal cell carcinoma
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U2 - 10.5173/ceju.2015.656
DO - 10.5173/ceju.2015.656
M3 - Article
C2 - 26855793
AN - SCOPUS:84951164992
SN - 2080-4806
VL - 68
SP - 415
EP - 420
JO - Central European Journal of Urology
JF - Central European Journal of Urology
IS - 4
ER -