Evaluation of oxidative stress status and antioxidant capacity in patients with painful bladder syndrome/interstitial cystitis: preliminary results of a randomised study

Kemal Ener, Murat Keske, Mustafa Aldemir, Muhammet Fuat Özcan, Emrah Okulu, Asım Özayar, Merve Ergin, Ömer Gökhan Doluoğlu, Serdar Çakmak, Özcan Erel

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: This study aimed to investigate oxidative stress in etiopathogenesis by analyzing serum total antioxidant capacity (TAC), total oxidant status (TOS), binding capacity of exogenous cobalt to human albumin (IMA), serum advanced oxidation protein products (AOPP), paraoxonase (PON), arylesterase, IgE, and C-reactive protein (CRP) in bladder pain syndrome/interstitial cystitis (BPS/IC). Methods: The study included 16 female patients diagnosed with BPS/IC and 25 healthy female subjects forming the control group. A bladder biopsy was performed on all patients in the BPS/IC group by carrying out cystoscopy with hydrodistention under general anesthesia. The results of serum TAC, TOS, IMA, AOPP, PON, arylesterase, IgE, and CRP of the subjects in both groups were compared. Results: The mean age of the 16 female patients in the BPS/IC group was 43.6 ± 14.5 years, and the mean age of the 25 healthy subjects in the control group was 42.0 ± 10.3 years. According to the criteria of International Society for the Study of Interstitial Cystitis (ESSIC), eight patients were classified as Type 2A, three patients as Type 2B, four patients as Type 2C, and one patient as Type 3C. In the BPS/IC group, while TAC was found significantly lower than in the control group, IMA, IgE, and CRP were found significantly higher (P 

Original languageEnglish (US)
Pages (from-to)1297-1302
Number of pages6
JournalInternational Urology and Nephrology
Volume47
Issue number8
DOIs
StatePublished - Aug 31 2015

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Interstitial Cystitis
Oxidative Stress
Antioxidants
Urinary Bladder
Pain
Advanced Oxidation Protein Products
C-Reactive Protein
Immunoglobulin E
Aryldialkylphosphatase
Oxidants
Control Groups
Healthy Volunteers
Cystoscopy
Cobalt
Serum
Serum Albumin
General Anesthesia
Biopsy

Keywords

  • Interstitial cystitis
  • Oxidative stress
  • Total antioxidant capacity
  • Total oxidant status

ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

Evaluation of oxidative stress status and antioxidant capacity in patients with painful bladder syndrome/interstitial cystitis : preliminary results of a randomised study. / Ener, Kemal; Keske, Murat; Aldemir, Mustafa; Özcan, Muhammet Fuat; Okulu, Emrah; Özayar, Asım; Ergin, Merve; Doluoğlu, Ömer Gökhan; Çakmak, Serdar; Erel, Özcan.

In: International Urology and Nephrology, Vol. 47, No. 8, 31.08.2015, p. 1297-1302.

Research output: Contribution to journalArticle

Ener, Kemal ; Keske, Murat ; Aldemir, Mustafa ; Özcan, Muhammet Fuat ; Okulu, Emrah ; Özayar, Asım ; Ergin, Merve ; Doluoğlu, Ömer Gökhan ; Çakmak, Serdar ; Erel, Özcan. / Evaluation of oxidative stress status and antioxidant capacity in patients with painful bladder syndrome/interstitial cystitis : preliminary results of a randomised study. In: International Urology and Nephrology. 2015 ; Vol. 47, No. 8. pp. 1297-1302.
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T1 - Evaluation of oxidative stress status and antioxidant capacity in patients with painful bladder syndrome/interstitial cystitis

T2 - preliminary results of a randomised study

AU - Ener, Kemal

AU - Keske, Murat

AU - Aldemir, Mustafa

AU - Özcan, Muhammet Fuat

AU - Okulu, Emrah

AU - Özayar, Asım

AU - Ergin, Merve

AU - Doluoğlu, Ömer Gökhan

AU - Çakmak, Serdar

AU - Erel, Özcan

PY - 2015/8/31

Y1 - 2015/8/31

N2 - Purpose: This study aimed to investigate oxidative stress in etiopathogenesis by analyzing serum total antioxidant capacity (TAC), total oxidant status (TOS), binding capacity of exogenous cobalt to human albumin (IMA), serum advanced oxidation protein products (AOPP), paraoxonase (PON), arylesterase, IgE, and C-reactive protein (CRP) in bladder pain syndrome/interstitial cystitis (BPS/IC). Methods: The study included 16 female patients diagnosed with BPS/IC and 25 healthy female subjects forming the control group. A bladder biopsy was performed on all patients in the BPS/IC group by carrying out cystoscopy with hydrodistention under general anesthesia. The results of serum TAC, TOS, IMA, AOPP, PON, arylesterase, IgE, and CRP of the subjects in both groups were compared. Results: The mean age of the 16 female patients in the BPS/IC group was 43.6 ± 14.5 years, and the mean age of the 25 healthy subjects in the control group was 42.0 ± 10.3 years. According to the criteria of International Society for the Study of Interstitial Cystitis (ESSIC), eight patients were classified as Type 2A, three patients as Type 2B, four patients as Type 2C, and one patient as Type 3C. In the BPS/IC group, while TAC was found significantly lower than in the control group, IMA, IgE, and CRP were found significantly higher (P 

AB - Purpose: This study aimed to investigate oxidative stress in etiopathogenesis by analyzing serum total antioxidant capacity (TAC), total oxidant status (TOS), binding capacity of exogenous cobalt to human albumin (IMA), serum advanced oxidation protein products (AOPP), paraoxonase (PON), arylesterase, IgE, and C-reactive protein (CRP) in bladder pain syndrome/interstitial cystitis (BPS/IC). Methods: The study included 16 female patients diagnosed with BPS/IC and 25 healthy female subjects forming the control group. A bladder biopsy was performed on all patients in the BPS/IC group by carrying out cystoscopy with hydrodistention under general anesthesia. The results of serum TAC, TOS, IMA, AOPP, PON, arylesterase, IgE, and CRP of the subjects in both groups were compared. Results: The mean age of the 16 female patients in the BPS/IC group was 43.6 ± 14.5 years, and the mean age of the 25 healthy subjects in the control group was 42.0 ± 10.3 years. According to the criteria of International Society for the Study of Interstitial Cystitis (ESSIC), eight patients were classified as Type 2A, three patients as Type 2B, four patients as Type 2C, and one patient as Type 3C. In the BPS/IC group, while TAC was found significantly lower than in the control group, IMA, IgE, and CRP were found significantly higher (P 

KW - Interstitial cystitis

KW - Oxidative stress

KW - Total antioxidant capacity

KW - Total oxidant status

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JO - International Urology and Nephrology

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SN - 0301-1623

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