Lokalize prostat kanseri ve benign prostat hiperplazi hastalarında oksidatif stres durumu ve antioksidan kapasitenin değerlendirilmesi

Translated title of the contribution: Evaluation of oxidative stress status and antioxidant capacity in patients with localized prostate cancer and benign prostatic hyperplasia

Mustafa Aldemir, Yücel Altay, Emrah Okulu, Kemal Ener, Asım Özayar, Cem Nedim Yücetürk, Özcan Erel

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Aim: The aim of this study was to evaluate the oxidative stress status and antioxidant capacity in patients with localized prostate cancer (PCa) and benign prostatic hyperplasia (BPH). Material and Method: The prospective study consisting 24 men with PCa and 36 men with BPH. PCa or BPH were di-agnosed histologically. Blood samples were obtained following an overnight fasting state. We evaluated and compared the total oxidant status (TOS), total antioxidant capacity (TAC), paraoxonase1 (PON1), arylesterase and to-tal thiol levels of patients with PCa and BPH. Results: The mean age of BPH group was 67 ± 12 years and PCa group was 63 ± 8 years (p>0.05). No statis-tically significant differences were detected between the groups in terms of oxidative stress parameters and antioxidant capacity measured in the serum of patients including PON1, TOS, TAC, arylesterase and thiols levels (p>0.05 for all parameters). Discussion: Our results demonstrated that evaluation of these parameters in the serum of BPH and localized PCa patients may not be used as a marker to discriminate between these diseases.

Translated title of the contributionEvaluation of oxidative stress status and antioxidant capacity in patients with localized prostate cancer and benign prostatic hyperplasia
Original languageTurkish
Pages (from-to)479-482
Number of pages4
JournalJournal of Clinical and Analytical Medicine
Volume6
Issue number4
DOIs
StatePublished - 2015

Keywords

  • Antioxidant capacity
  • Localized prostate cancer
  • Oxidative stress

ASJC Scopus subject areas

  • Medicine(all)

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