Evaluation of the FHIT gene in colorectal cancers

Sam Thiagalingam, Nikolai A. Lisitsyn, Masaaki Hamaguchi, Michael H. Wigler, James K V Willson, Sanford D. Markowitz, Frederick S. Leach, Kenneth W. Kinzler, Bert Vogelstein

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127 Scopus citations

Abstract

A variety of studies suggests that tumor suppressor loci on chromosome 3p are important in various forms of human neoplasia. Recently, a chromosome 3p14.2 gene called FHIT was discovered and proposed as a candidate tumor suppressor gene in colorectal and other cancers. We evaluated the FHIT gene in a panel of colorectal cancer cell lines and xenografts, which allowed a comprehensive mutational analysis. A transcript containing the complete coding sequence was found to be expressed at robust levels in 29 of 31 cancers tested. The complete sequence of the coding region of the gene was determined and found to be normal in all 29 of these cases. These studies suggest either that FHIT is inactivated by an unusual mechanism or that it plays a role in relatively few colorectal tumors.

Original languageEnglish (US)
Pages (from-to)2936-2939
Number of pages4
JournalCancer Research
Volume56
Issue number13
StatePublished - Jul 1 1996

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Thiagalingam, S., Lisitsyn, N. A., Hamaguchi, M., Wigler, M. H., Willson, J. K. V., Markowitz, S. D., Leach, F. S., Kinzler, K. W., & Vogelstein, B. (1996). Evaluation of the FHIT gene in colorectal cancers. Cancer Research, 56(13), 2936-2939.