Evaluation of triple quantum-filtered 23Na NMR spectroscopy in the in situ rat liver

Viswanathan Seshan, A. Dean Sherry, Navin Bansal

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Triple quantum (TQ)-filtered 23Na NMR spectroscopy and the shift reagent, TmDOTP5-, have been used to evaluate the contributions of intra- (Na(i)+) and extracellular (Na(e)+) sodium to the TQ-filtered signal in the rat liver, in situ. Na(e)+ contributed significantly to the total TQ- filtered signal in live animals, and the intensity of this signal did not change postmortem. The TQ-filtered Na(i)+ signal increased by approximately 380% over a period of 1 h postmortem, whereas the single quantum (SQ) Na(i)+ increased by 90%. The constancy of the TQ-filtered Na(e)+ signal indicates that changes in total TQ-filtered 23Na signal intensity in liver (without a shift reagent) may accurately reflect changes in TQ-filtered Na(i)+ signal intensity. The large percent increase in the TQ-filtered Na(i)+ signal as compared to the SQ signal suggests that the fraction of Na(i)+ interacting with macromolecules increases after death.

Original languageEnglish (US)
Pages (from-to)821-827
Number of pages7
JournalMagnetic resonance in medicine
Volume38
Issue number5
DOIs
StatePublished - Nov 1997

Keywords

  • Liver
  • Multiple quantum NMR
  • Na MRS
  • Shift reagent

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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