Evaluation of visual-evoked cerebral metabolic rate of oxygen as a diagnostic marker in multiple sclerosis

Nicholas A. Hubbard, Yoel Sanchez Araujo, Camila Caballero, Minhui Ouyang, Monroe P. Turner, Lyndahl Himes, Shawheen Faghihahmadabadi, Binu P. Thomas, John Hart, Hao Huang, Darin Okuda, Bart Rypma

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A multiple sclerosis (MS) diagnosis often relies upon clinical presentation and qualitative analysis of standard, magnetic resonance brain images. However, the accuracy of MS diagnoses can be improved by utilizing advanced brain imaging methods.We assessed the accuracy of a new neuroimaging marker, visual-evoked cerebral metabolic rate of oxygen (veCMRO2), in classifying MS patients and closely age- and sex-matched healthy control (HC) participants. MS patients and HCs underwent calibrated functional magnetic resonance imaging (cfMRI) during a visual stimulation task, diffusion tensor imaging, T1- and T2-weighted imaging, neuropsychological testing, and completed self-report questionnaires. Using resampling techniques to avoid bias and increase the generalizability of the results, we assessed the accuracy of veCMRO2 in classifying MS patients and HCs. veCMRO2 classification accuracy was also examined in the context of other evoked visuofunctional measures, white matter microstructural integrity, lesion-based measures from T2-weighted imaging, atrophy measures from T1-weighted imaging, neuropsychological tests, and self-report assays of clinical symptomology. veCMRO2 was significant and within the top 16% of measures (43 total) in classifying MS status using both within-sample (82% accuracy) and out-of-sample (77% accuracy) observations. High accuracy of veCMRO2 in classifying MS demonstrated an encouraging first step toward establishing veCMRO2 as a neurodiagnostic marker of MS.

Original languageEnglish (US)
Article number64
JournalBrain Sciences
Volume7
Issue number6
DOIs
StatePublished - Jun 11 2017

Fingerprint

Multiple Sclerosis
Oxygen
Neuroimaging
Self Report
Photic Stimulation
Diffusion Tensor Imaging
Neuropsychological Tests
Atrophy
Healthy Volunteers
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Brain

Keywords

  • Calibrated functional magnetic resonance imaging
  • Diagnosis
  • Metabolism
  • Multiple sclerosis
  • Visual system

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Evaluation of visual-evoked cerebral metabolic rate of oxygen as a diagnostic marker in multiple sclerosis. / Hubbard, Nicholas A.; Araujo, Yoel Sanchez; Caballero, Camila; Ouyang, Minhui; Turner, Monroe P.; Himes, Lyndahl; Faghihahmadabadi, Shawheen; Thomas, Binu P.; Hart, John; Huang, Hao; Okuda, Darin; Rypma, Bart.

In: Brain Sciences, Vol. 7, No. 6, 64, 11.06.2017.

Research output: Contribution to journalArticle

Hubbard, NA, Araujo, YS, Caballero, C, Ouyang, M, Turner, MP, Himes, L, Faghihahmadabadi, S, Thomas, BP, Hart, J, Huang, H, Okuda, D & Rypma, B 2017, 'Evaluation of visual-evoked cerebral metabolic rate of oxygen as a diagnostic marker in multiple sclerosis', Brain Sciences, vol. 7, no. 6, 64. https://doi.org/10.3390/brainsci7060064
Hubbard, Nicholas A. ; Araujo, Yoel Sanchez ; Caballero, Camila ; Ouyang, Minhui ; Turner, Monroe P. ; Himes, Lyndahl ; Faghihahmadabadi, Shawheen ; Thomas, Binu P. ; Hart, John ; Huang, Hao ; Okuda, Darin ; Rypma, Bart. / Evaluation of visual-evoked cerebral metabolic rate of oxygen as a diagnostic marker in multiple sclerosis. In: Brain Sciences. 2017 ; Vol. 7, No. 6.
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