Evasion and disruption of innate immune signalling by hepatitis C and West Nile viruses

Mehul S. Suthar, Michael Gale, David M. Owen

Research output: Contribution to journalShort survey

20 Scopus citations

Abstract

Signalling pathways leading to type I interferon production are the first line of defence employed by the host to combat viruses, and represent a barrier that an invading virus must overcome in order to establish infection. In this review we highlight the ability of two members of the Flaviviridae, a globally distributed family of RNA viruses that represent a significant public health concern, to disrupt and evade these defences. Hepatitis C virus is a hepatotropic virus, infecting greater than 170 million people worldwide, while West Nile virus is a neurotropic virus that causes encephalitis in humans and horses. While these viruses cause distinct disease phenotypes, the ability of pathogenic strains to modulate the innate immune response is a key factor in influencing disease outcome. Both viruses have evolved unique strategies to target various aspects of type I interferon induction and signalling in order to prevent viral clearance and to promote virus replication.

Original languageEnglish (US)
Pages (from-to)880-888
Number of pages9
JournalCellular Microbiology
Volume11
Issue number6
DOIs
StatePublished - May 14 2009

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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