TY - JOUR
T1 - Evasion and disruption of innate immune signalling by hepatitis C and West Nile viruses
AU - Suthar, Mehul S.
AU - Gale, Michael
AU - Owen, David M.
PY - 2009
Y1 - 2009
N2 - Signalling pathways leading to type I interferon production are the first line of defence employed by the host to combat viruses, and represent a barrier that an invading virus must overcome in order to establish infection. In this review we highlight the ability of two members of the Flaviviridae, a globally distributed family of RNA viruses that represent a significant public health concern, to disrupt and evade these defences. Hepatitis C virus is a hepatotropic virus, infecting greater than 170 million people worldwide, while West Nile virus is a neurotropic virus that causes encephalitis in humans and horses. While these viruses cause distinct disease phenotypes, the ability of pathogenic strains to modulate the innate immune response is a key factor in influencing disease outcome. Both viruses have evolved unique strategies to target various aspects of type I interferon induction and signalling in order to prevent viral clearance and to promote virus replication.
AB - Signalling pathways leading to type I interferon production are the first line of defence employed by the host to combat viruses, and represent a barrier that an invading virus must overcome in order to establish infection. In this review we highlight the ability of two members of the Flaviviridae, a globally distributed family of RNA viruses that represent a significant public health concern, to disrupt and evade these defences. Hepatitis C virus is a hepatotropic virus, infecting greater than 170 million people worldwide, while West Nile virus is a neurotropic virus that causes encephalitis in humans and horses. While these viruses cause distinct disease phenotypes, the ability of pathogenic strains to modulate the innate immune response is a key factor in influencing disease outcome. Both viruses have evolved unique strategies to target various aspects of type I interferon induction and signalling in order to prevent viral clearance and to promote virus replication.
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U2 - 10.1111/j.1462-5822.2009.01311.x
DO - 10.1111/j.1462-5822.2009.01311.x
M3 - Short survey
C2 - 19341437
AN - SCOPUS:65549134705
SN - 1462-5814
VL - 11
SP - 880
EP - 888
JO - Cellular Microbiology
JF - Cellular Microbiology
IS - 6
ER -