Evidence-based gallbladder cancer staging

Changing cancer staging by analysis of data from the national cancer database

Yuman Fong, Lawrence Wagman, Mithat Gonen, James Crawford, William Reed, Richard Swanson, Charlie Pan, Jamie Ritchey, Andrew Stewart, Michael A Choti

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

BACKGROUND: A recent revision of the American Joint Committee on Cancer (AJCC) staging for gallbladder cancer (6th Edition) involved some major changes. Most notably, T2N0M0 tumors were moved from stage II to stage IB; T3N1M0 disease was moved from stage III to stage IIB; and T4NxM0 (x = any) tumors were moved from stage IVA to stage III. METHODS: In order to determine if these changes were justified by data, an analysis of the 10,705 cases of gallbladder cancer collected between 1989 and 1996 in the NCDB was performed. All patients had >5 year follow-up. RESULTS: The staging according to the 6th Edition provided no discrimination between stage III and IV. Five-year survivals for stage IIA, IIB, III, and IV (6th Edition) were 7%, 9%, 3%, 2% respectively. The data from the National Cancer Database (NCDB) were used to derive a proposed new staging system that builds upon Edition 5 and had improved discrimination of stage groups over previous editions. CONCLUSIONS: Changes in staging systems should be justified by data. Multicenter databases, including the NCDB, represent important resources for verification of evidence-based staging systems.

Original languageEnglish (US)
Pages (from-to)767-771
Number of pages5
JournalAnnals of surgery
Volume243
Issue number6
DOIs
StatePublished - Jun 1 2006
Externally publishedYes

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Gallbladder Neoplasms
Neoplasm Staging
Databases
Neoplasms
Reoperation
Survival

ASJC Scopus subject areas

  • Surgery

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Evidence-based gallbladder cancer staging : Changing cancer staging by analysis of data from the national cancer database. / Fong, Yuman; Wagman, Lawrence; Gonen, Mithat; Crawford, James; Reed, William; Swanson, Richard; Pan, Charlie; Ritchey, Jamie; Stewart, Andrew; Choti, Michael A.

In: Annals of surgery, Vol. 243, No. 6, 01.06.2006, p. 767-771.

Research output: Contribution to journalArticle

Fong, Y, Wagman, L, Gonen, M, Crawford, J, Reed, W, Swanson, R, Pan, C, Ritchey, J, Stewart, A & Choti, MA 2006, 'Evidence-based gallbladder cancer staging: Changing cancer staging by analysis of data from the national cancer database', Annals of surgery, vol. 243, no. 6, pp. 767-771. https://doi.org/10.1097/01.sla.0000219737.81943.4e
Fong, Yuman ; Wagman, Lawrence ; Gonen, Mithat ; Crawford, James ; Reed, William ; Swanson, Richard ; Pan, Charlie ; Ritchey, Jamie ; Stewart, Andrew ; Choti, Michael A. / Evidence-based gallbladder cancer staging : Changing cancer staging by analysis of data from the national cancer database. In: Annals of surgery. 2006 ; Vol. 243, No. 6. pp. 767-771.
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