Evidence for a functional role of dopamine type-1 (D-1) receptors in the substantia nigra of rats

Roberts T. Matthews, Dwight C. German

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The microiontophoretic application of dopamine onto neurons in the substantia nigra of rats increased the spontaneous activity of zona reticulata (ZR) neurons but decreased the activity of zone compacta (ZC) neurons. The systemic administration of the dopamine antagonists, haloperidol and cis-flupentixol, blocked the dopamine effects. However, haloperidol was more potent on ZC neurons that on ZR neurons whereas cis-flupentixol was of comparable potency on ZC and ZR neurons. In addition, microiontopheretic application of a cyclic adenosine monophosphate analog was found to mimic the effects of dopamine on ZR neurons, but not on ZC neurons. Taken together with receptor binding studies on the relative affinities of haloperidol and cis-flupentixol for various dopamine receptor subtypes, these data suggest that the excitatory effect of dopamine on ZR neurons is mediated by a D-1 type receptor whereas its inhibitory effect on the ZC dopaminergic neuron is mediated by a D-2 type receptor.

Original languageEnglish (US)
Pages (from-to)87-93
Number of pages7
JournalEuropean Journal of Pharmacology
Volume120
Issue number1
DOIs
StatePublished - Jan 14 1986

Keywords

  • D-1 receptors
  • Dopamine
  • Neuroleptics
  • Substantia nigra
  • cAMP

ASJC Scopus subject areas

  • Pharmacology

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