Evidence for a role of Collapsin response mediator protein-2 in signaling pathways that regulate the proliferation of non-neuronal cells

Candice Ginn T Tahimic, Nozomi Tomimatsu, Ryuichi Nishigaki, Akiko Fukuhara, Tosifusa Toda, Kozo Kaibuchi, Goshi Shiota, Mitsuo Oshimura, Akihiro Kurimasa

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Collapsin response mediator protein-2 or Crmp-2 plays a critical role in the establishment of neuronal polarity. In this study, we present evidence that apart from its functions in neurodevelopment, Crmp-2 is also involved in pathways that regulate the proliferation of non-neuronal cells through its phosphorylation by regulatory proteins. We show that Crmp-2 undergoes dynamic phosphorylation changes in response to contact inhibition-induced quiescence and that hyperphosphorylation of Crmp-2 occurs in a tumor. We further suggest that de-regulation of Crmp-2 phosphorylation levels at certain amino acid residues may lead to aberrant cell proliferation and consequently, tumorigenesis.

Original languageEnglish (US)
Pages (from-to)1244-1250
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume340
Issue number4
DOIs
StatePublished - Feb 24 2006

Keywords

  • ATM kinase
  • Cell proliferation
  • Collapsin response mediator protein-2
  • Contact inhibition
  • GSK3β
  • Phosphorylation
  • Quiescence
  • Rho kinase
  • Tumorigenesis

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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