Abstract
Collapsin response mediator protein-2 or Crmp-2 plays a critical role in the establishment of neuronal polarity. In this study, we present evidence that apart from its functions in neurodevelopment, Crmp-2 is also involved in pathways that regulate the proliferation of non-neuronal cells through its phosphorylation by regulatory proteins. We show that Crmp-2 undergoes dynamic phosphorylation changes in response to contact inhibition-induced quiescence and that hyperphosphorylation of Crmp-2 occurs in a tumor. We further suggest that de-regulation of Crmp-2 phosphorylation levels at certain amino acid residues may lead to aberrant cell proliferation and consequently, tumorigenesis.
Original language | English (US) |
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Pages (from-to) | 1244-1250 |
Number of pages | 7 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 340 |
Issue number | 4 |
DOIs | |
State | Published - Feb 24 2006 |
Keywords
- ATM kinase
- Cell proliferation
- Collapsin response mediator protein-2
- Contact inhibition
- GSK3β
- Phosphorylation
- Quiescence
- Rho kinase
- Tumorigenesis
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology