Evidence for minor structural variations of class II genes in wild and inbred mice

E. K. Wakeland, J. Klein

Research output: Contribution to journalArticle

6 Scopus citations


We organized 29 B10.W lines into eight antigenic groups on the basis of similarities in the antigenic phenotypes of their class II antigens. Tryptic peptide finger-print comparisons of class II antigens in different antigenic groups detected structural variations in 30 to 60% of the tryptic peptides. In contrast, less than 10% of the tryptic peptides were distinguishable in comparisons of class II antigens within the same antigenic group. These results suggest structurally discrete allelic families of class II genes exist in wild mouse populations.

Original languageEnglish (US)
Pages (from-to)1280-1287
Number of pages8
JournalJournal of Immunology
Issue number3
StatePublished - Jan 1 1983


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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