Evidence that murine Vγ5 and Vγ6 γδ-TCR+ lymphocytes are derived from a common distinct lineage

K. Heyborne, Y. X. Fu, H. Kalataradi, C. Reardon, C. Roark, C. Eyster, M. Vollmer, W. Born, R. O'Brien

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Murine Vγ5 and Vγ6+ T lymphocytes develop sequentially in the thymus during fetal and newborn life, giving rise to intraepithelial lymphocytes of the epidermis and female reproductive tract. In analyzing a panel of γδ T cell hybridomas derived from various tissues, we found that all Vγ6+ cells tested (n = 25) expressed Vγ5-Cγ1 mRNA, whereas none of a panel of Vγ6- cells analyzed (n = 33) expressed this mRNA. Vγ6 mRNA was rare in Vγ5+ cells (1 of 9), and absent in all other γδ T cells (n = 10). These findings suggest that most, if not all, Vγ6-TCR+ lymphocytes arise from precursor cells that have previously rearranged the Vγ5 gene, and indicate that Vγ5 and Vγ6+ lymphocytes belong to a common, distinct lineage that does not give rise to other γδ T cells.

Original languageEnglish (US)
Pages (from-to)4523-4527
Number of pages5
JournalJournal of Immunology
Issue number9
StatePublished - 1993

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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