Evidence that RpoS (σS) in Borrelia burgdorferi is controlled directly by RpoN (σ54N)

Alexandra H. Smith, Jon S. Blevins, Gulnaz N. Bachlani, Xiaofeng F. Yang, Michael V. Norgard

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

The alternative sigma factor (RpoN-RpoS) pathway controls the expression of key virulence factors in Borrelia burgdorferi. However, evidence to support whether RpoN controls rpoS directly or, perhaps, indirectly via a transactivator has been lacking. Herein we provide biochemical and genetic evidence that RpoN directly controls rpoS in B. burgdorferi.

Original languageEnglish (US)
Pages (from-to)2139-2144
Number of pages6
JournalJournal of bacteriology
Volume189
Issue number5
DOIs
StatePublished - Mar 2007

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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