Evidence that the fate of class II-dispartate corneal grafts is determined by the timing of class II expression

J. Ross, D. Callanan, H. Kunz, J. Niederkorn

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

While the immune privilege nature of the eye affords significant protection to corneal grafts, immunologic rejection is the leading cause of graft failure. Class II antigens are normally absent or expressed at very low levels in normal cornea. The role that class II antigens play in causing graft rejection is particularly interesting. Class II molecules are present on many cells of the immune system, and therefore are important in modulating and mediating immune reactions. The absence of class II bearing cells in the cornea leads to the interesting issue of whether or not those antigens can induce immune rejection of a corneal graft. In the current study we have made use of a pair of congenic rat strains that differ only at class II loci to determine the impact of these antigens on corneal graft survival. Central corneal grafts were not rejected. Recipients preimmunized with skin grafts rejected 100% of the class II disparate corneas with a median survival time (MST) of 15.5 days. When class II disparate Langerhans-cell-containing (LC+) corneas were grafted, the corneas were not rejected, but they immunized the recipients as evidenced by the rejection of a second corneal graft on the contralateral eye. Immunofluorescent stains demonstrated transient expression of class II antigens on graft epithelium after transplantation. This temporary appearance of class II provides a target for rejection in the preimmunized animals but is of insufficient duration to both prime naive animals and provide a target for antigraft effectors.

Original languageEnglish (US)
Pages (from-to)532-536
Number of pages5
JournalTransplantation
Volume51
Issue number2
StatePublished - 1991

Fingerprint

Cornea
Transplants
Histocompatibility Antigens Class II
Graft Rejection
Antigens
Langerhans Cells
Graft Survival
Immune System
Coloring Agents
Epithelium
Transplantation
Skin

ASJC Scopus subject areas

  • Immunology
  • Transplantation

Cite this

Evidence that the fate of class II-dispartate corneal grafts is determined by the timing of class II expression. / Ross, J.; Callanan, D.; Kunz, H.; Niederkorn, J.

In: Transplantation, Vol. 51, No. 2, 1991, p. 532-536.

Research output: Contribution to journalArticle

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