Evidence that the rad1 and rad10 proteins of Saccharomyces cerevisiae participate as a complex in nucleotide excision repair of UV radiation damage

W. Siede, A. S. Friedberg, E. C. Friedberg

Research output: Contribution to journalComment/debate

12 Scopus citations

Abstract

A newly characterized rad1 missense mutation (rad1-20) in the yeast Saccharomyces cerevisiae maps to a region of the Rad1 polypeptide known to be required for Rad1-Rad10 complex formation. The UV sensitivity of the rad1-20 mutant can be partially and specifically corrected by overexpression of wild- type Rad10 protein. These results suggest that complex formation between the Rad1 and Rad10 proteins is required for nucleotide excision repair.

Original languageEnglish (US)
Pages (from-to)6345-6347
Number of pages3
JournalJournal of bacteriology
Volume175
Issue number19
DOIs
StatePublished - Jan 1 1993

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ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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