Evodiamine inhibits adipogenesis via the EGFR-PKCα-ERK signaling pathway

Ting Wang, Youxue Wang, Hitoshi Yamashita

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

The molecular mechanism of the anti-adipogenic effect of evodiamine (which has several capsaicin-like pharmacological actions) was investigated. The evodiamine effect was not blocked by the specific TRPV1 antagonist capsazepine in 3T3-L1 preadipocytes, whereas its effect was greatly curtailed by inhibitors of protein kinase C (PKC) and epidermal growth factor receptor (EGFR). Signal analyses showed that evodiamine stimulated the phosphorylation of EGFR, PKCα, and ERK, all of which were reduced by an EGFR inhibitor. Silencing experiments of EGFR mRNA supported the involvement of these signaling molecules in the inhibitory effect of evodiamine. An unidentified mechanism whereby evodiamine inhibits adipogenesis via the EGFR-PKCα-ERK signaling pathway was revealed.

Original languageEnglish (US)
Pages (from-to)3655-3659
Number of pages5
JournalFEBS Letters
Volume583
Issue number22
DOIs
StatePublished - Nov 19 2009

Keywords

  • Adipogenesis
  • Epidermal growth factor receptor
  • Evodiamine
  • Extracellularly regulated kinase
  • Protein kinase C alpha

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'Evodiamine inhibits adipogenesis via the EGFR-PKCα-ERK signaling pathway'. Together they form a unique fingerprint.

  • Cite this