Evolution of Osteocrin as an activity-regulated factor in the primate brain

Bulent Ataman, Gabriella L. Boulting, David A. Harmin, Marty G. Yang, Mollie Baker-Salisbury, Ee Lynn Yap, Athar N. Malik, Kevin Mei, Alex A. Rubin, Ivo Spiegel, Ershela Durresi, Nikhil Sharma, Linda S. Hu, Mihovil Pletikos, Eric C. Griffith, Jennifer N. Partlow, Christine R. Stevens, Mazhar Adli, Maria Chahrour, Nenad SestanChristopher A. Walsh, Vladimir K. Berezovskii, Margaret S. Livingstone, Michael E. Greenberg

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Sensory stimuli drive the maturation and function of the mammalian nervous system in part through the activation of gene expression networks that regulate synapse development and plasticity. These networks have primarily been studied in mice, and it is not known whether there are species- or clade-specific activity-regulated genes that control features of brain development and function. Here we use transcriptional profiling of human fetal brain cultures to identify an activity-dependent secreted factor, Osteocrin (OSTN), that is induced by membrane depolarization of human but not mouse neurons. We find that OSTN has been repurposed in primates through the evolutionary acquisition of DNA regulatory elements that bind the activity-regulated transcription factor MEF2. In addition, we demonstrate that OSTN is expressed in primate neocortex and restricts activity-dependent dendritic growth in human neurons. These findings suggest that, in response to sensory input, OSTN regulates features of neuronal structure and function that are unique to primates.

Original languageEnglish (US)
Pages (from-to)242-247
Number of pages6
JournalNature
Volume539
Issue number7628
DOIs
StatePublished - Nov 9 2016

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Primates
Brain
MEF2 Transcription Factors
Neurons
Gene Regulatory Networks
Neocortex
Synapses
Nervous System
Gene Expression
Membranes
DNA
Growth
Genes

ASJC Scopus subject areas

  • General

Cite this

Ataman, B., Boulting, G. L., Harmin, D. A., Yang, M. G., Baker-Salisbury, M., Yap, E. L., ... Greenberg, M. E. (2016). Evolution of Osteocrin as an activity-regulated factor in the primate brain. Nature, 539(7628), 242-247. https://doi.org/10.1038/nature20111

Evolution of Osteocrin as an activity-regulated factor in the primate brain. / Ataman, Bulent; Boulting, Gabriella L.; Harmin, David A.; Yang, Marty G.; Baker-Salisbury, Mollie; Yap, Ee Lynn; Malik, Athar N.; Mei, Kevin; Rubin, Alex A.; Spiegel, Ivo; Durresi, Ershela; Sharma, Nikhil; Hu, Linda S.; Pletikos, Mihovil; Griffith, Eric C.; Partlow, Jennifer N.; Stevens, Christine R.; Adli, Mazhar; Chahrour, Maria; Sestan, Nenad; Walsh, Christopher A.; Berezovskii, Vladimir K.; Livingstone, Margaret S.; Greenberg, Michael E.

In: Nature, Vol. 539, No. 7628, 09.11.2016, p. 242-247.

Research output: Contribution to journalArticle

Ataman, B, Boulting, GL, Harmin, DA, Yang, MG, Baker-Salisbury, M, Yap, EL, Malik, AN, Mei, K, Rubin, AA, Spiegel, I, Durresi, E, Sharma, N, Hu, LS, Pletikos, M, Griffith, EC, Partlow, JN, Stevens, CR, Adli, M, Chahrour, M, Sestan, N, Walsh, CA, Berezovskii, VK, Livingstone, MS & Greenberg, ME 2016, 'Evolution of Osteocrin as an activity-regulated factor in the primate brain', Nature, vol. 539, no. 7628, pp. 242-247. https://doi.org/10.1038/nature20111
Ataman B, Boulting GL, Harmin DA, Yang MG, Baker-Salisbury M, Yap EL et al. Evolution of Osteocrin as an activity-regulated factor in the primate brain. Nature. 2016 Nov 9;539(7628):242-247. https://doi.org/10.1038/nature20111
Ataman, Bulent ; Boulting, Gabriella L. ; Harmin, David A. ; Yang, Marty G. ; Baker-Salisbury, Mollie ; Yap, Ee Lynn ; Malik, Athar N. ; Mei, Kevin ; Rubin, Alex A. ; Spiegel, Ivo ; Durresi, Ershela ; Sharma, Nikhil ; Hu, Linda S. ; Pletikos, Mihovil ; Griffith, Eric C. ; Partlow, Jennifer N. ; Stevens, Christine R. ; Adli, Mazhar ; Chahrour, Maria ; Sestan, Nenad ; Walsh, Christopher A. ; Berezovskii, Vladimir K. ; Livingstone, Margaret S. ; Greenberg, Michael E. / Evolution of Osteocrin as an activity-regulated factor in the primate brain. In: Nature. 2016 ; Vol. 539, No. 7628. pp. 242-247.
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