Abstract
Within the ever-expanding repertoire of known protein sequences and structures, many examples of evolving three-dimensional structures are emerging that illustrate the plasticity and robustness of protein folds. The mechanisms by which protein folds change often include the fusion of duplicated domains, followed by divergence through mutation. Such changes reflect both the stability of protein folds and the requirements of protein function.
Original language | English (US) |
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Pages (from-to) | 400-408 |
Number of pages | 9 |
Journal | Current Opinion in Structural Biology |
Volume | 12 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1 2002 |
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology