TY - JOUR
T1 - Evolving Characteristics of Heart Transplantation Donors and Recipients
T2 - JACC Focus Seminar
AU - DeFilippis, Ersilia M.
AU - Khush, Kiran K.
AU - Farr, Maryjane A.
AU - Fiedler, Amy
AU - Kilic, Arman
AU - Givertz, Michael M.
N1 - Publisher Copyright:
© 2022 American College of Cardiology Foundation
PY - 2022/3/22
Y1 - 2022/3/22
N2 - Although the burden of end-stage heart failure continues to increase, the number of available organs for heart transplantation (HT) remains inadequate. The HT community has been challenged to find ways to expand the number of donor hearts available. Recent advances include use of hearts from donors infected with hepatitis C virus as well as other previously underutilized donors, including those with left ventricular dysfunction, of older age, and with a history of cocaine use. Concurrently, emerging trends in HT surgery include donation after circulatory death, ex vivo normothermic heart perfusion, and controlled hypothermic preservation, which may enable procurement of organs from farther distances and prevent early allograft dysfunction. Contemporary HT recipients have also evolved in light of the 2018 revision to the U.S. heart allocation policy. This focus seminar discusses recent trends in donor and recipient phenotypes and management strategies for successful HT, as well as evolving areas and future directions.
AB - Although the burden of end-stage heart failure continues to increase, the number of available organs for heart transplantation (HT) remains inadequate. The HT community has been challenged to find ways to expand the number of donor hearts available. Recent advances include use of hearts from donors infected with hepatitis C virus as well as other previously underutilized donors, including those with left ventricular dysfunction, of older age, and with a history of cocaine use. Concurrently, emerging trends in HT surgery include donation after circulatory death, ex vivo normothermic heart perfusion, and controlled hypothermic preservation, which may enable procurement of organs from farther distances and prevent early allograft dysfunction. Contemporary HT recipients have also evolved in light of the 2018 revision to the U.S. heart allocation policy. This focus seminar discusses recent trends in donor and recipient phenotypes and management strategies for successful HT, as well as evolving areas and future directions.
KW - donation after circulatory death
KW - donor selection
KW - ex vivo normothermic perfusion
KW - heart failure
KW - heart transplantation
KW - hepatitis C virus
UR - http://www.scopus.com/inward/record.url?scp=85125725397&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85125725397&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2021.11.064
DO - 10.1016/j.jacc.2021.11.064
M3 - Review article
C2 - 35300823
AN - SCOPUS:85125725397
SN - 0735-1097
VL - 79
SP - 1108
EP - 1123
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 11
ER -