Abstract
Lung carcinogenesis is a complex, stepwise process that involves the acquisition of genetic mutations and epigenetic changes that alter cellular processes, such as proliferation, differentiation, invasion, and metastasis. Here, we review some of the latest concepts in the pathogenesis of lung cancer and highlight the roles of inflammation, the field of cancerization, and lung cancer stem cells in the initiation of the disease. Furthermore, we review how high throughput genomics, transcriptomics, epigenomics, and proteomics are advancing the study of lung carcinogenesis. Finally, we reflect on the potential of current in vitro and in vivo models of lung carcinogenesis to advance the field and on the areas of investigation where major breakthroughs will lead to the identification of novel chemoprevention strategies and therapies for lung cancer.
Original language | English (US) |
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Pages (from-to) | 32-43 |
Number of pages | 12 |
Journal | Seminars in Respiratory and Critical Care Medicine |
Volume | 32 |
Issue number | 1 |
DOIs | |
State | Published - 2011 |
Keywords
- Field of cancerization
- epigenomics
- genomics
- inflammation
- proteomics
- stem cells
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Critical Care and Intensive Care Medicine