Excretion of citrate by metacestodes of Mesocestoides vogae

I. Corbin, J. Payette, B. J. Blackburn, M. Novak

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

When metacestodes of Mesocestoides vogae were incubated with oxaloacetate, the 1H NMR spectra of the incubation media established the presence of citrate in addition to the usual worm excretory products succinate, acetate, alanine, and lactate. Given the known impermeability of the inner mitochondrial membrane to multiply charged matrix metabolites, the finding strongly suggests the presence of a transporter to convey citrate from the mitochondria to the cytosol. It is proposed that some of the extramitochondrial citrate serves as a source of cytosolic acetyl-CoA, via the citrate lyase reaction, for conversion to malonyl-CoA and subsequent fatty acid chain elongation. The data demonstrate that because citrate is excreted, further forward steps in the tricarboxylic acid cycle are either very slow or not operating.

Original languageEnglish (US)
Pages (from-to)1783-1786
Number of pages4
JournalCanadian Journal of Zoology
Volume76
Issue number9
StatePublished - Sep 1998

Fingerprint

Mesocestoides corti
metacestodes
mitochondrion
excretion
citrates
nuclear magnetic resonance
metabolite
acetate
fatty acid
incubation
membrane
matrix
acid
malonyl coenzyme A
tricarboxylic acid cycle
lyases
succinic acid
cytosol
alanine
lactates

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Corbin, I., Payette, J., Blackburn, B. J., & Novak, M. (1998). Excretion of citrate by metacestodes of Mesocestoides vogae. Canadian Journal of Zoology, 76(9), 1783-1786.

Excretion of citrate by metacestodes of Mesocestoides vogae. / Corbin, I.; Payette, J.; Blackburn, B. J.; Novak, M.

In: Canadian Journal of Zoology, Vol. 76, No. 9, 09.1998, p. 1783-1786.

Research output: Contribution to journalArticle

Corbin, I, Payette, J, Blackburn, BJ & Novak, M 1998, 'Excretion of citrate by metacestodes of Mesocestoides vogae', Canadian Journal of Zoology, vol. 76, no. 9, pp. 1783-1786.
Corbin I, Payette J, Blackburn BJ, Novak M. Excretion of citrate by metacestodes of Mesocestoides vogae. Canadian Journal of Zoology. 1998 Sep;76(9):1783-1786.
Corbin, I. ; Payette, J. ; Blackburn, B. J. ; Novak, M. / Excretion of citrate by metacestodes of Mesocestoides vogae. In: Canadian Journal of Zoology. 1998 ; Vol. 76, No. 9. pp. 1783-1786.
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