Exercise and Prostate Cancer Risk in a Cohort of Veterans Undergoing Prostate Needle Biopsy

Jodi A. Antonelli, Lee W. Jones, Lionel L. Bañez, Jean Alfred Thomas, Kelly Anderson, Loretta A. Taylor, Leah Gerber, Tiffany Anderson, Catherine Hoyo, Delores Grant, Stephen J. Freedland

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Purpose: Epidemiological and molecular evidence suggest potential associations between exercise and prostate cancer risk reduction. We further characterized this relationship by examining exercise and cancer risk among men undergoing prostate needle biopsy. Materials and Methods: A total of 190 men who underwent prostate biopsy at the Durham Veterans Affairs Medical Center completed a questionnaire on current exercise behavior. Participants were asked average frequency of mild, moderate and strenuous intensity exercise in a typical week, as well as average duration as assessed by the Godin Leisure Time Exercise Questionnaire. Total current exercise was calculated in terms of metabolic equivalent task hours per week. Primary outcome measures were prostate biopsy result and Gleason sum. Results: After adjusting for age, race, body mass index, prostate specific antigen, digital rectal examination, family history, previous prostate biopsy and comorbidity score, men who reported 9 or more metabolic equivalent task hours per week of exercise were significantly less likely to have cancer on biopsy (OR 0.35, CI 0.17-0.75, p = 0.007). Furthermore, among men with malignant biopsy results, reporting moderate exercise (3 to 8.9 metabolic equivalent task hours weekly) was associated with a lower risk of high grade disease (Gleason 7 or greater, OR 0.14, CI 0.02-0.94, p = 0.04). Conclusions: To our knowledge these results provide the first evidence of an association between exercise and prostate cancer risk as well as grade at diagnosis in men scheduled to undergo prostate biopsy. Specifically moderate exercise was associated with a lower risk of prostate cancer and in men with cancer, lower grade disease. Further investigation using an objective measure of exercise in a larger sample size is required to confirm these findings.

Original languageEnglish (US)
Pages (from-to)2226-2231
Number of pages6
JournalJournal of Urology
Volume182
Issue number5
DOIs
StatePublished - Nov 2009

Fingerprint

Needle Biopsy
Veterans
Prostate
Prostatic Neoplasms
Exercise
Metabolic Equivalent
Biopsy
Digital Rectal Examination
Neoplasms
Leisure Activities
Risk Reduction Behavior
Prostate-Specific Antigen
Sample Size
Comorbidity
Body Mass Index
Outcome Assessment (Health Care)

Keywords

  • exercise
  • prostatic neoplasms
  • risk factors

ASJC Scopus subject areas

  • Urology
  • Medicine(all)

Cite this

Antonelli, J. A., Jones, L. W., Bañez, L. L., Thomas, J. A., Anderson, K., Taylor, L. A., ... Freedland, S. J. (2009). Exercise and Prostate Cancer Risk in a Cohort of Veterans Undergoing Prostate Needle Biopsy. Journal of Urology, 182(5), 2226-2231. https://doi.org/10.1016/j.juro.2009.07.028

Exercise and Prostate Cancer Risk in a Cohort of Veterans Undergoing Prostate Needle Biopsy. / Antonelli, Jodi A.; Jones, Lee W.; Bañez, Lionel L.; Thomas, Jean Alfred; Anderson, Kelly; Taylor, Loretta A.; Gerber, Leah; Anderson, Tiffany; Hoyo, Catherine; Grant, Delores; Freedland, Stephen J.

In: Journal of Urology, Vol. 182, No. 5, 11.2009, p. 2226-2231.

Research output: Contribution to journalArticle

Antonelli, JA, Jones, LW, Bañez, LL, Thomas, JA, Anderson, K, Taylor, LA, Gerber, L, Anderson, T, Hoyo, C, Grant, D & Freedland, SJ 2009, 'Exercise and Prostate Cancer Risk in a Cohort of Veterans Undergoing Prostate Needle Biopsy', Journal of Urology, vol. 182, no. 5, pp. 2226-2231. https://doi.org/10.1016/j.juro.2009.07.028
Antonelli, Jodi A. ; Jones, Lee W. ; Bañez, Lionel L. ; Thomas, Jean Alfred ; Anderson, Kelly ; Taylor, Loretta A. ; Gerber, Leah ; Anderson, Tiffany ; Hoyo, Catherine ; Grant, Delores ; Freedland, Stephen J. / Exercise and Prostate Cancer Risk in a Cohort of Veterans Undergoing Prostate Needle Biopsy. In: Journal of Urology. 2009 ; Vol. 182, No. 5. pp. 2226-2231.
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abstract = "Purpose: Epidemiological and molecular evidence suggest potential associations between exercise and prostate cancer risk reduction. We further characterized this relationship by examining exercise and cancer risk among men undergoing prostate needle biopsy. Materials and Methods: A total of 190 men who underwent prostate biopsy at the Durham Veterans Affairs Medical Center completed a questionnaire on current exercise behavior. Participants were asked average frequency of mild, moderate and strenuous intensity exercise in a typical week, as well as average duration as assessed by the Godin Leisure Time Exercise Questionnaire. Total current exercise was calculated in terms of metabolic equivalent task hours per week. Primary outcome measures were prostate biopsy result and Gleason sum. Results: After adjusting for age, race, body mass index, prostate specific antigen, digital rectal examination, family history, previous prostate biopsy and comorbidity score, men who reported 9 or more metabolic equivalent task hours per week of exercise were significantly less likely to have cancer on biopsy (OR 0.35, CI 0.17-0.75, p = 0.007). Furthermore, among men with malignant biopsy results, reporting moderate exercise (3 to 8.9 metabolic equivalent task hours weekly) was associated with a lower risk of high grade disease (Gleason 7 or greater, OR 0.14, CI 0.02-0.94, p = 0.04). Conclusions: To our knowledge these results provide the first evidence of an association between exercise and prostate cancer risk as well as grade at diagnosis in men scheduled to undergo prostate biopsy. Specifically moderate exercise was associated with a lower risk of prostate cancer and in men with cancer, lower grade disease. Further investigation using an objective measure of exercise in a larger sample size is required to confirm these findings.",
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