Exercise-induced skeletal muscle adaptations alter the activity of adipose progenitor cells

Daniel Zeve, Douglas P. Millay, Jin Seo, Jonathan M. Graff

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Exercise decreases adiposity and improves metabolic health; however, the physiological and molecular underpinnings of these phenomena remain unknown. Here, we investigate the effect of endurance training on adipose progenitor lineage commitment. Using mice with genetically labeled adipose progenitors, we show that these cells react to exercise by decreasing their proliferation and differentiation potential. Analyses of mouse models that mimic the skeletal muscle adaptation to exercise indicate that muscle, in a non-autonomous manner, regulates adipose progenitor homeostasis, highlighting a role for muscle-derived secreted factors. These findings support a humoral link between skeletal muscle and adipose progenitors and indicate that manipulation of adipose stem cell function may help address obesity and diabetes.

Original languageEnglish (US)
Article numbere0152129
JournalPloS one
Volume11
Issue number3
DOIs
StatePublished - Mar 2016

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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